LEMD3

This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane.
Full Name
LEM DOMAIN CONTAINING 3
Function
Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.
Biological Process
Negative regulation of activin receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of BMP signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Nuclear envelope organizationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of intracellular signal transductionIEA:InterPro
Cellular Location
Nucleus inner membrane
Involvement in disease
Buschke-Ollendorff syndrome (BOS):
A disease characterized by osteopoikilosis and disseminated connective-tissue nevi. Osteopoikilosis is a skeletal dysplasia characterized by a symmetric but unequal distribution of multiple hyperostotic areas in different parts of the skeleton. Elastic-type nevi (juvenile elastoma) and collagen-type nevi (dermatofibrosis lenticularis disseminata) have been described in BOS. Skin or bony lesions can be absent in some family members, whereas other relatives may have both.
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Anti-LEMD3 antibodies

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Mouse Anti-LEMD3 Recombinant Antibody (CBFYM-1211) (CBMAB-M1368-FY)

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Target: LEMD3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Monkey
Clone: CBFYM-1211
Application*: WB, F
Datasheet SDS

Mouse Anti-LEMD3 Recombinant Antibody (CBFYM-1210) (CBMAB-M1367-FY)

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Target: LEMD3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-1210
Application*: WB, P, F, IF
Datasheet SDS

Mouse Anti-LEMD3 Recombinant Antibody (6C10) (CBMAB-L1099-YJ)

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Target: LEMD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6C10
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-LEMD3 Recombinant Antibody (4E1) (CBMAB-L1098-YJ)

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Target: LEMD3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4E1
Application*: F, IC, IF, P, WB
Datasheet SDS

Mouse Anti-LEMD3 Recombinant Antibody (3H2) (CBMAB-L1097-YJ)

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Target: LEMD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Monkey
Clone: 3H2
Application*: IC, IF, WB
Datasheet SDS

Mouse Anti-LEMD3 Recombinant Antibody (3H1) (CBMAB-L1096-YJ)

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Target: LEMD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat, Monkey
Clone: 3H1
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-LEMD3 Recombinant Antibody (CBYJL-1425) (CBMAB-L1095-YJ)

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Target: LEMD3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-1425
Application*: F, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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