Mouse Anti-LEMD3 Recombinant Antibody (CBFYM-1211) (CBMAB-M1368-FY)

This product is mouse antibody that recognizes LEMD3. The antibody CBFYM-1211 can be used for immunoassay techniques such as: WB, FC.
See all LEMD3 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Monkey

Clone

CBFYM-1211

Antibody Isotype

IgG2b

Application

WB, FC

Basic Information

Specificity

Human, Monkey

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

LEM DOMAIN CONTAINING 3

Introduction

This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane.

Entrez Gene ID

Human	23592
Monkey	717597

UniProt ID

Human	Q9Y2U8
Monkey	A0A2K5VT79

Alternative Names

MAN1

Function

Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.

Biological Process

Negative regulation of activin receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of BMP signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Nuclear envelope organizationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of intracellular signal transductionIEA:InterPro

Cellular Location

Nucleus inner membrane

Involvement in disease

Buschke-Ollendorff syndrome (BOS):
A disease characterized by osteopoikilosis and disseminated connective-tissue nevi. Osteopoikilosis is a skeletal dysplasia characterized by a symmetric but unequal distribution of multiple hyperostotic areas in different parts of the skeleton. Elastic-type nevi (juvenile elastoma) and collagen-type nevi (dermatofibrosis lenticularis disseminata) have been described in BOS. Skin or bony lesions can be absent in some family members, whereas other relatives may have both.

References

Xu, Z., Yang, C., & Xue, R. (2021). Buschke‐Ollendorff syndrome with LEMD3 germline stopgain mutation p. R678* presenting as multiple subcutaneous nodules with mucin deposition. Journal of Cutaneous Pathology, 48(1), 77-80.

Ji, D., Chen, G. F., Wang, J. C., Ji, S. H., Wu, X. W., Lu, X. J., ... & Li, J. T. (2020). Hsa_circ_0070963 inhibits liver fibrosis via regulation of miR-223-3p and LEMD3. Aging (Albany NY), 12(2), 1643.

Frost, M., Rahbek, E. T., Ejersted, C., Høilund-Carlsen, P. F., Bygum, A., Thomsen, J. S., ... & Frederiksen, A. L. (2020). Modeling-based bone formation transforms trabeculae to cortical bone in the sclerotic areas in Buschke-Ollendorff syndrome. A case study of two females with LEMD3 variants. Bone, 135, 115313.

Llano, M. G. C., Mora, J., Torner, F., Inarejos, E., & Cruz, O. (2020). Osteopoikilosis with germline LEMD3 mutation mimicking bone metastases in a girl with a concurrent secreting mixed germ cell tumor. Journal of Pediatric Hematology/Oncology, 42(3), e185-e187.

Elmaoğulları, S., Yıldız, A. E., Demir, S., Gürkan, H., & Uçaktürk, S. A. (2019). A novel LEMD3 pathogenic variant in a son and mother with osteopoikilosis. The Turkish Journal of Pediatrics, 61(4), 594-598.

Silov, G., Erdoğan, Z., Erdoğan, M., Özdal, A., Gençer, H., Akalın, T., & Karaçavuş, S. (2018). Tc-99m MDP bone SPECT/CT findings of a patient detected with a new mutation in LEMD3 gene: a case of osteopoikilosis. Molecular Imaging and Radionuclide Therapy, 27(1), 48.

Q & As

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Review & reward

Have you used Mouse Anti-LEMD3 Recombinant Antibody (CBFYM-1211)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-LEMD3 Recombinant Antibody (4E1)

Mouse Anti-LEMD3 Recombinant Antibody (CBYJL-1425)

Mouse Anti-LEMD3 Recombinant Antibody (3H1)

Mouse Anti-LEMD3 Recombinant Antibody (3H2)

Mouse Anti-LEMD3 Recombinant Antibody (CBFYM-1210)

Mouse Anti-LEMD3 Recombinant Antibody (6C10)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote

Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email: