Lgl1

Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. LLGL1 scribble cell polarity complex component is involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. LLGL1 scribble cell polarity complex component is involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane.

Full Name

Llgl1 Scribble Cell Polarity Complex Component

Function

Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane.

Biological Process

AxonogenesisISS:UniProtKB
Brain developmentManual Assertion Based On ExperimentTAS:UniProtKB
Cortical actin cytoskeleton organizationISO:MGI
Establishment of spindle orientationManual Assertion Based On ExperimentIBA:GO_Central
ExocytosisIEA:UniProtKB-KW
Golgi to plasma membrane transportISS:UniProtKB
Maintenance of apical/basal cell polarityManual Assertion Based On ExperimentIMP:MGI
Protein-containing complex assemblyISO:MGI
Regulation of establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Regulation of Notch signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Regulation of protein secretionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Early endosome membrane
Golgi apparatus, trans-Golgi network membrane
Golgi apparatus membrane
Cell projection, axon
Cytoplasm, cytoskeleton
Localized to the lateral membrane during the polarization and formation cell-cell contacts. Enriched in developing axons (By similarity).

PTM

Phosphorylated by PRKCI on at least one of the following Ser residues: Ser 654, Ser-658, Ser-662, Ser-669 and Ser-672. Phosphorylation is important for appropriated cell polarization.