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Rat Anti-Lgl1 Recombinant Antibody (4D11) (CBMAB-L2734-YJ)

Provided herein is a Rat monoclonal antibody, which binds to Llgl1 Scribble Cell Polarity Complex Component (Lgl1). The antibody can be used for immunoassay techniques, such as FC.
See all Lgl1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
4D11
Antibody Isotype
IgG2a
Application
FC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Llgl1 Scribble Cell Polarity Complex Component
Introduction
Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. LLGL1 scribble cell polarity complex component is involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. LLGL1 scribble cell polarity complex component is involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane.
Entrez Gene ID
16897
UniProt ID
Q80Y17
Alternative Names
Lgl1; Mgl1; Llglh; AI325176; lethal(2) giant larvae protein homolog 1; LLGL; lethal giant larvae homolog 1; mgl-1; mlgl
Function
Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane.
Biological Process
AxonogenesisISS:UniProtKB
Brain developmentManual Assertion Based On ExperimentTAS:UniProtKB
Cortical actin cytoskeleton organizationISO:MGI
Establishment of spindle orientationManual Assertion Based On ExperimentIBA:GO_Central
ExocytosisIEA:UniProtKB-KW
Golgi to plasma membrane transportISS:UniProtKB
Maintenance of apical/basal cell polarityManual Assertion Based On ExperimentIMP:MGI
Protein-containing complex assemblyISO:MGI
Regulation of establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Regulation of Notch signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Regulation of protein secretionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Early endosome membrane
Golgi apparatus, trans-Golgi network membrane
Golgi apparatus membrane
Cell projection, axon
Cytoplasm, cytoskeleton
Localized to the lateral membrane during the polarization and formation cell-cell contacts. Enriched in developing axons (By similarity).
PTM
Phosphorylated by PRKCI on at least one of the following Ser residues: Ser 654, Ser-658, Ser-662, Ser-669 and Ser-672. Phosphorylation is important for appropriated cell polarization.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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