LIG3

This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Full Name
LIG3
Function
Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627).
Biological Process
Base-excision repair, DNA ligationManual Assertion Based On ExperimentIDA:BHF-UCL
Base-excision repair, gap-fillingTAS:Reactome
Cell cycleIEA:UniProtKB-KW
Cell divisionIEA:UniProtKB-KW
DNA biosynthetic processIEA:InterPro
DNA ligationManual Assertion Based On ExperimentIDA:BHF-UCL
Double-strand break repairManual Assertion Based On ExperimentIDA:BHF-UCL
Double-strand break repair via alternative nonhomologous end joiningManual Assertion Based On ExperimentIGI:BHF-UCL
Double-strand break repair via homologous recombinationTAS:Reactome
Lagging strand elongationManual Assertion Based On ExperimentIBA:GO_Central
Mitochondrial DNA repairManual Assertion Based On ExperimentIMP:BHF-UCL
Mitochondrion organizationIDA:BHF-UCL
Negative regulation of mitochondrial DNA replicationManual Assertion Based On ExperimentIMP:CACAO
Cellular Location
Isoform 1&2:
Mitochondrion
Contains an N-terminal mitochondrial transit peptide.
Isoform 3&4:
Nucleus
Lacks the N-terminal mitochondrial transit peptide.
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Anti-LIG3 antibodies

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Mouse Anti-LIG3 Recombinant Antibody (2F3) (CBMAB-0696-CN)

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Target: LIG3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 2F3
Application*: E, M
Datasheet SDS

Mouse Anti-LIG3 Recombinant Antibody (CBYJL-1662) (CBMAB-L1532-YJ)

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Target: LIG3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1662
Application*: WB
Datasheet SDS

Mouse Anti-LIG3 Recombinant Antibody (4H9) (CBMAB-L1531-YJ)

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Target: LIG3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4H9
Application*: IP, WB
Datasheet SDS

Mouse Anti-LIG3 Recombinant Antibody (CBYJL-1661) (CBMAB-L1530-YJ)

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Target: LIG3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1661
Application*: P, WB
Datasheet SDS

Mouse Anti-LIG3 Recombinant Antibody (CBYJL-1660) (CBMAB-L1529-YJ)

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Target: LIG3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1660
Application*: WB
Datasheet SDS

Mouse Anti-LIG3 Recombinant Antibody (7/DNA Ligase III) (CBMAB-D2111-YC)

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Target: LIG3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Mouse, Rat
Clone: 7/DNA Ligase III
Application*: WB
Datasheet SDS

Mouse Anti-LIG3 Recombinant Antibody (6G9) (CBMAB-D2110-YC)

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Target: LIG3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6G9
Application*: WB, P, F, IC, IF
Datasheet SDS

Mouse Anti-LIG3 Recombinant Antibody (1F3) (CBMAB-D2108-YC)

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Target: LIG3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Chicken, Mouse
Clone: 1F3
Application*: IC, IF, N, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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