Sign in or Register   Sign in or Register
  |  

Mouse Anti-LIG3 Recombinant Antibody (1F3) (CBMAB-D2108-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DNA Ligase 3 (LIG3). The antibody can be used for immunoassay techniques, such as ICC, IF, Neut, WB.
See all LIG3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Chicken, Mouse
Clone
1F3
Antibody Isotype
IgG1
Application
ICC, IF, Neut, WB

Basic Information

Immunogen
Recombinant full-length human DNA Ligase III-b
Specificity
Human, Chicken, Mouse
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LIG3
Introduction
LIG3 is a member of the DNA ligase family. LIG3 is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus.
Entrez Gene ID
Human3980
Mouse16882
Chicken417530
UniProt ID
HumanP49916
MouseP97386
ChickenF1P394
Alternative Names
LIG2
Function
Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627).
Biological Process
Base-excision repair, DNA ligationManual Assertion Based On ExperimentIDA:BHF-UCL
Base-excision repair, gap-fillingTAS:Reactome
Cell cycleIEA:UniProtKB-KW
Cell divisionIEA:UniProtKB-KW
DNA biosynthetic processIEA:InterPro
DNA ligationManual Assertion Based On ExperimentIDA:BHF-UCL
Double-strand break repairManual Assertion Based On ExperimentIDA:BHF-UCL
Double-strand break repair via alternative nonhomologous end joiningManual Assertion Based On ExperimentIGI:BHF-UCL
Double-strand break repair via homologous recombinationTAS:Reactome
Lagging strand elongationManual Assertion Based On ExperimentIBA:GO_Central
Mitochondrial DNA repairManual Assertion Based On ExperimentIMP:BHF-UCL
Mitochondrion organizationIDA:BHF-UCL
Negative regulation of mitochondrial DNA replicationManual Assertion Based On ExperimentIMP:CACAO
Cellular Location
Isoform 1&2:
Mitochondrion
Contains an N-terminal mitochondrial transit peptide.
Isoform 3&4:
Nucleus
Lacks the N-terminal mitochondrial transit peptide.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-LIG3 Recombinant Antibody (1F3)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare