LMCD1

This gene encodes a member of the LIM-domain family of zinc finger proteins. The encoded protein contains an N-terminal cysteine-rich domain and two C-terminal LIM domains. The presence of LIM domains suggests involvement in protein-protein interactions. The protein may act as a co-regulator of transcription along with other transcription factors. Alternate splicing results in multiple transcript variants of this gene.

LIM and cysteine rich domains 1

Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity).
Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.

Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Positive regulation of calcineurin-NFAT signaling cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cardiac muscle hypertrophyManual Assertion Based On ExperimentIMP:UniProtKB

Cytoplasm
Nucleus
May shuttle between the cytoplasm and the nucleus.