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LMCD1

This gene encodes a member of the LIM-domain family of zinc finger proteins. The encoded protein contains an N-terminal cysteine-rich domain and two C-terminal LIM domains. The presence of LIM domains suggests involvement in protein-protein interactions. The protein may act as a co-regulator of transcription along with other transcription factors. Alternate splicing results in multiple transcript variants of this gene.

Full Name

LIM and cysteine rich domains 1

Function

Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity).
Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.

Biological Process

Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Positive regulation of calcineurin-NFAT signaling cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cardiac muscle hypertrophyManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm
Nucleus
May shuttle between the cytoplasm and the nucleus.

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Anti-LMCD1 antibodies

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Mouse Anti-LMCD1 Recombinant Antibody (CBYJL-1810) (CBMAB-L1755-YJ)

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Target: LMCD1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJL-1810

Application*: WB, IP, IF, E

Mouse Anti-LMCD1 Recombinant Antibody (2F12) (CBMAB-L1754-YJ)

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Target: LMCD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2F12

Application*: F, WB

Mouse Anti-LMCD1 Recombinant Antibody (1H5) (CBMAB-L1753-YJ)

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Target: LMCD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1H5

Application*: WB, F, IH, IC, IF, P

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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