LMCD1

This gene encodes a member of the LIM-domain family of zinc finger proteins. The encoded protein contains an N-terminal cysteine-rich domain and two C-terminal LIM domains. The presence of LIM domains suggests involvement in protein-protein interactions. The protein may act as a co-regulator of transcription along with other transcription factors. Alternate splicing results in multiple transcript variants of this gene.
Full Name
LIM and cysteine rich domains 1
Function
Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity).
Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.
Biological Process
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Positive regulation of calcineurin-NFAT signaling cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cardiac muscle hypertrophyManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Nucleus
May shuttle between the cytoplasm and the nucleus.
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Anti-LMCD1 antibodies

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Mouse Anti-LMCD1 Recombinant Antibody (CBYJL-1810) (CBMAB-L1755-YJ)

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Target: LMCD1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1810
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-LMCD1 Recombinant Antibody (2F12) (CBMAB-L1754-YJ)

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Target: LMCD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F12
Application*: F, WB
Datasheet SDS

Mouse Anti-LMCD1 Recombinant Antibody (1H5) (CBMAB-L1753-YJ)

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Target: LMCD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1H5
Application*: WB, F, IH, IC, IF, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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