LPXN

Leupaxin is a transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). It contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. It suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). It may play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. It negatively regulates B-cell antigen receptor (BCR) signaling.

Full Name

leupaxin

Function

Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.

Biological Process

Cell adhesion1 PublicationNAS:ProtInc
Endothelial cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of B cell receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Protein-containing complex assemblyManual Assertion Based On ExperimentTAS:ProtInc
Regulation of cell adhesion mediated by integrinIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIBA:GO_Central
Transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Cell junction, focal adhesion
Nucleus
Cytoplasm, perinuclear region
Cell projection, podosome
Cell membrane
Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B-cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin.

PTM

Phosphorylated on tyrosine residues. Phosphorylation on Tyr-72 is important for its inhibitory function. Bombesin stimulates phosphorylation on Tyr-22, Tyr-62 and Tyr-72.