LRPAP1
This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants.
Full Name
LDL receptor related protein associated protein 1
Function
Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway.
Biological Process
Amyloid-beta clearance by transcytosisManual Assertion Based On ExperimentIMP:ARUK-UCL
Extracellular negative regulation of signal transductionManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Negative regulation of amyloid-beta clearanceManual Assertion Based On ExperimentIGI:BHF-UCL
Negative regulation of cell deathManual Assertion Based On ExperimentIGI:ARUK-UCL
Negative regulation of protein bindingManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of receptor internalizationManual Assertion Based On ExperimentIGI:ARUK-UCL
Negative regulation of very-low-density lipoprotein particle clearanceManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of amyloid-beta clearanceManual Assertion Based On ExperimentTAS:ARUK-UCL
Regulation of receptor-mediated endocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Extracellular negative regulation of signal transductionManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Negative regulation of amyloid-beta clearanceManual Assertion Based On ExperimentIGI:BHF-UCL
Negative regulation of cell deathManual Assertion Based On ExperimentIGI:ARUK-UCL
Negative regulation of protein bindingManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of receptor internalizationManual Assertion Based On ExperimentIGI:ARUK-UCL
Negative regulation of very-low-density lipoprotein particle clearanceManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of amyloid-beta clearanceManual Assertion Based On ExperimentTAS:ARUK-UCL
Regulation of receptor-mediated endocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Rough endoplasmic reticulum lumen
Endoplasmic reticulum-Golgi intermediate compartment lumen
Golgi apparatus, cis-Golgi network
Golgi apparatus lumen
Endosome lumen
Cell surface
May be associated with receptors at the cell surface.
Endoplasmic reticulum-Golgi intermediate compartment lumen
Golgi apparatus, cis-Golgi network
Golgi apparatus lumen
Endosome lumen
Cell surface
May be associated with receptors at the cell surface.
Involvement in disease
Myopia 23, autosomal recessive (MYP23):
A refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far.
A refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far.
PTM
N-glycosylated.
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Anti-LRPAP1 antibodies
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CompareTarget: LRPAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 105
Application*: E
Target: LRPAP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 9
Application*: E, P
Target: LRPAP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 11
Application*: P
Target: LRPAP1
Host: Mouse
Specificity: Human
Clone: E-7
Application*: WB, IP, IF, E
Target: LRPAP1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBCNR-191
Application*: WB
Target: LRPAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F3
Application*: E, WB
Target: LRPAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCL-474
Application*: IF, IH, WB
Target: Lrpap1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJL-2487
Application*: P
Target: Lrpap1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJL-2486
Application*: WB, E, P, IP
Target: LRPAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AT8G8
Application*: E, WB
Target: LRPAP1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 9L447
Application*: WB
Target: LRPAP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 8G8
Application*: WB, E
Target: LRPAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7F1
Application*: E, P, WB
Target: LRPAP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1994
Application*: WB, E, IC, IF, IP
Target: LRPAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 34
Application*: WB
Target: LRPAP1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1D6F3B4
Application*: WB, E, P, IP
Target: LRPAP1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1993
Application*: E, WB
Target: LRPAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1992
Application*: E, IP
Target: LRPAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1991
Application*: P
Target: LRPAP1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 29-360
Tag: His Tag
Target: LRPAP1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 35-357
Tag: His Tag
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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