Human Recombinant LRPAP1 protein, His Tag (V2LY-0526-LY5359)

Name: Human Recombinant LRPAP1 protein, His Tag
SKU: V2LY-0526-LY5359
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant LRPAP1 protein, His Tag consist of Amino Acid: 35-357 and predicts a molecular mass of 39.2 kDa.

Molecule Mass

39.2 kDa

Verified

HPLC

Sequence

Amino Acid: 35-357

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥92% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

LDL receptor related protein associated protein 1

Function

Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway.

Biological Process

Amyloid-beta clearance by transcytosisManual Assertion Based On ExperimentIMP:ARUK-UCL
Extracellular negative regulation of signal transductionManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Negative regulation of amyloid-beta clearanceManual Assertion Based On ExperimentIGI:BHF-UCL
Negative regulation of cell deathManual Assertion Based On ExperimentIGI:ARUK-UCL
Negative regulation of protein bindingManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of receptor internalizationManual Assertion Based On ExperimentIGI:ARUK-UCL
Negative regulation of very-low-density lipoprotein particle clearanceManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of amyloid-beta clearanceManual Assertion Based On ExperimentTAS:ARUK-UCL
Regulation of receptor-mediated endocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Rough endoplasmic reticulum lumen
Endoplasmic reticulum-Golgi intermediate compartment lumen
Golgi apparatus, cis-Golgi network
Golgi apparatus lumen
Endosome lumen
Cell surface
May be associated with receptors at the cell surface.

Involvement in disease

Myopia 23, autosomal recessive (MYP23):
A refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far.

PTM

N-glycosylated.

Li, H., Wang, X., Wang, Y., Li, Y., Chen, Y., Wong, Y. T., ... & He, M. L. (2023). Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity. Signal Transduction and Targeted Therapy, 8(1), 374.

Reid, K. M., & Brown, G. C. (2023). LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation. Frontiers in Immunology, 14.

Liu, S., Chen, T., Chen, B., Liu, Y., Lu, X., & Li, J. (2022). Lrpap1 deficiency leads to myopia through TGF-β-induced apoptosis in zebrafish. Cell Communication and Signaling, 20(1), 162.

Podgórska, D., Cieśla, M., Majdan, M., Podgórski, R., & Kolarz, B. (2021). The relationship of ADAMTSL2 and LRPAP1 gene methylation level with rheumatoid arthritis activity. Clinical and Experimental Rheumatology.

Thurner, L., Fadle, N., Bittenbring, J. T., Regitz, E., Schuck, R., Cetin, O., ... & Hoster, E. (2021). LRPAP1 autoantibodies in mantle cell lymphoma are associated with superior outcome. Blood, The Journal of the American Society of Hematology, 137(23), 3251-3258.

Bewarder, M., Kiefer, M., Will, H., Olesch, K., Moelle, C., Stilgenbauer, S., ... & Thurner, L. (2021). The B-cell receptor autoantigen LRPAP1 can replace variable antibody regions to target mantle cell lymphoma cells. HemaSphere, 5(8).

Sumazaki, M., Shimada, H., Ito, M., Shiratori, F., Kobayashi, E., Yoshida, Y., ... & Hiwasa, T. (2020). Serum anti‐LRPAP1 is a common biomarker for digestive organ cancers and atherosclerotic diseases. Cancer science, 111(12), 4453-4464.

Magliyah, M. S., Alsulaiman, S. M., Nowilaty, S. R., Alkuraya, F. S., & Schatz, P. (2020). Rhegmatogenous retinal detachment in nonsyndromic high myopia associated with recessive mutations in LRPAP1. Ophthalmology Retina, 4(1), 77-83.

Thurner, L., Hartmann, S., Fadle, N., Kemele, M., Bock, T., Bewarder, M., ... & Pfreundschuh, M. (2019). LRPAP1 is a frequent proliferation-inducing antigen of BCRs of mantle cell lymphomas and can be used for specific therapeutic targeting. Leukemia, 33(1), 148-158.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Recombinant LRPAP1 protein, His Tag (CAT#: V2LY-0526-LY8627)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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