LRRC8D

LRRC8C is a non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine and plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress.

leucine rich repeat containing 8D

Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:32415200).
The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731).
Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731).
LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471).
Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24782309, PubMed:24790029, PubMed:26824658, PubMed:28193731).
Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (By similarity).
VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122).
Mediates the import of the antibiotic blasticidin-S into the cell (PubMed:24782309).

Anion transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Aspartate transmembrane transportManual Assertion Based On ExperimentIMP:UniProtKB
Cellular glucose homeostasisISS:UniProtKB
Cellular response to osmotic stressManual Assertion Based On ExperimentIMP:UniProtKB
Protein hexamerizationManual Assertion Based On ExperimentIDA:UniProtKB
Taurine transportManual Assertion Based On ExperimentIMP:UniProtKB

Cell membrane
Endoplasmic reticulum membrane
In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum (PubMed:24782309, PubMed:24790029).
Requires LRRC8A for expression at the cell membrane (PubMed:24790029).

Cytoplasmic: 1-22
Helical: 23-48
Extracellular: 49-163
Helical: 164-182
Cytoplasmic: 183-308
Helical: 309-328
Extracellular: 329-360
Helical: 361-386
Cytoplasmic: 387-858