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Mouse Anti-LRRC8D Recombinant Antibody (CBYJL-2026) (CBMAB-L2139-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Leucine Rich Repeat Containing 8 Vrac Subunit D (LRRC8D). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all LRRC8D antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYJL-2026
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
leucine rich repeat containing 8D
Introduction
An important paralog of this gene is LRRC8A.
Entrez Gene ID
Human55144
Mouse231549
Rat305131
UniProt ID
HumanQ7L1W4
MouseQ8BGR2
RatQ5U308
Alternative Names
LRRC5; volume-regulated anion channel subunit LRRC8D; leucine rich repeat containing 5; leucine rich repeat containing 8 family member D; leucine-rich repeat-containing protein 5; leucine-rich repeat-containing protein 8D
Function
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:32415200).
The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731).
Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731).
LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471).
Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24782309, PubMed:24790029, PubMed:26824658, PubMed:28193731).
Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (By similarity).
VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122).
Mediates the import of the antibiotic blasticidin-S into the cell (PubMed:24782309).
Biological Process
Anion transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Aspartate transmembrane transportManual Assertion Based On ExperimentIMP:UniProtKB
Cellular glucose homeostasisISS:UniProtKB
Cellular response to osmotic stressManual Assertion Based On ExperimentIMP:UniProtKB
Protein hexamerizationManual Assertion Based On ExperimentIDA:UniProtKB
Taurine transportManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Endoplasmic reticulum membrane
In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum (PubMed:24782309, PubMed:24790029).
Requires LRRC8A for expression at the cell membrane (PubMed:24790029).
Topology
Cytoplasmic: 1-22
Helical: 23-48
Extracellular: 49-163
Helical: 164-182
Cytoplasmic: 183-308
Helical: 309-328
Extracellular: 329-360
Helical: 361-386
Cytoplasmic: 387-858
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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