MAGED1

This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Full Name
MAGE Family Member D1
Function
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.
Biological Process
Circadian regulation of gene expressionISS:UniProtKB
Negative regulation of epithelial cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein localization to nucleusIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of apoptotic signaling pathwayIEA:Ensembl
Positive regulation of branching involved in ureteric bud morphogenesisIEA:Ensembl
Positive regulation of MAP kinase activityIEA:Ensembl
Regulation of apoptotic processManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of circadian rhythmIEA:Ensembl
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Cytoplasm
Cell membrane
Nucleus
Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.
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Anti-MAGED1 antibodies

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Mouse Anti-MAGED1 Recombinant Antibody (1G11) (CBMAB-A5169-LY)

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Target: MAGED1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1G11
Application*: WB, E
Datasheet SDS

Mouse Anti-MAGED1 Recombinant Antibody (1E1) (CBMAB-A5168-LY)

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Target: MAGED1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1E1
Application*: WB, E
Datasheet SDS

Mouse Anti-MAGED1 Recombinant Antibody (CBFYM-1332) (CBMAB-M1491-FY)

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Target: MAGED1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-1332
Application*: F, IC, IF
Datasheet SDS

Mouse Anti-MAGED1 (AA 117-226) Recombinant Antibody (CBFYM-1331) (CBMAB-M1490-FY)

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Target: MAGED1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-1331
Application*: P, SE, E, WB
Datasheet SDS

Mouse Anti-MAGED1 (AA 1-778) Recombinant Antibody (CBFYM-1330) (CBMAB-M1489-FY)

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Target: MAGED1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-1330
Application*: E, WB
Datasheet SDS

Mouse Anti-MAGED1 (AA 117-226) Recombinant Antibody (CBFYM-1329) (CBMAB-M1488-FY)

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Target: MAGED1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-1329
Application*: E, P, WB
Datasheet SDS

Mouse Anti-MAGED1 (AA 20-224) Recombinant Antibody (CBFYM-1328) (CBMAB-M1487-FY)

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Target: MAGED1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-1328
Application*: WB
Datasheet SDS

Mouse Anti-MAGED1 Recombinant Antibody (H-7) (CBMAB-N0949-WJ)

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Target: MAGED1
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: H-7
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-MAGED1 Recombinant Antibody (CBWJN-1133) (CBMAB-N0948-WJ)

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Target: MAGED1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBWJN-1133
Application*: WB, IC
Datasheet SDS

Mouse Anti-MAGED1 Recombinant Antibody (CBWJN-0933) (CBMAB-N0083-WJ)

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Target: MAGED1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-0933
Application*: F, IC
Datasheet SDS

MAGED1 Matched Antibody Pair (709) (APMAB-709LY)

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Target: MAGED1
Specificity: Human
Datasheet SDS

MAGED1 Matched Antibody Pair (708) (APMAB-708LY)

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Target: MAGED1
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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