Human MAGED1 ELISA Kit (V2LY-0626-LY4877)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0089 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
86.2 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
MAGE Family Member D1
Function
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.
Biological Process
Circadian regulation of gene expressionISS:UniProtKB
Negative regulation of epithelial cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein localization to nucleusIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of apoptotic signaling pathwayIEA:Ensembl
Positive regulation of branching involved in ureteric bud morphogenesisIEA:Ensembl
Positive regulation of MAP kinase activityIEA:Ensembl
Regulation of apoptotic processManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of circadian rhythmIEA:Ensembl
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Cytoplasm
Cell membrane
Nucleus
Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.

Cheron, J., Beccari, L., Hagué, P., Icick, R., Despontin, C., Carusone, T., ... & de Kerchove d’Exaerde, A. (2023). USP7/Maged1-mediated H2A monoubiquitination in the paraventricular thalamus: an epigenetic mechanism involved in cocaine use disorder. Nature communications, 14(1), 8481.

Wang, J., Xu, S. Y., Ye, Z. Y., Sun, Z. N., Zhang, J. Q., Qi, C., ... & Gao, J. (2023). The deficiency of Maged1 attenuates Parkinson's disease progression in mice. Molecular Brain, 16(1), 1-16.

Park, S., Kwon, W., Kim, H. Y., Ji, Y. R., Kim, D., Kim, W., ... & Choi, S. K. (2022). Knockdown of Maged1 inhibits cell cycle progression and causes cell death in mouse embryonic stem cells. Differentiation, 125, 18-26.

Cheron, J., Beccari, L., Hagué, P., Icick, R., Despontin, C., Carusone, T., ... & de Kerchove d’Exaerde, A. (2022). USP7/Maged1-Mediated H2A Monoubiquitination in the Paraventricular Thalamus: An Epigenetic Mechanism Involved in Cocaine Use Disorder. bioRxiv, 2022-11.

Hu, L., Wang, J., Huang, H., Yu, Y., Ding, J., Yu, Y., ... & Chen, F. (2021). YTHDF1 regulates pulmonary hypertension through translational control of MAGED1. American journal of respiratory and critical care medicine, 203(9), 1158-1172.

Zhang, B., Li, D., Jin, X., & Zhang, K. (2020). The CDK4/6 inhibitor PD0332991 stabilizes FBP1 by repressing MAGED1 expression in pancreatic ductal adenocarcinoma. The International Journal of Biochemistry & Cell Biology, 128, 105859.

Wang, J., You, W. Y., Ye, Q., Zhang, J. Q., He, C., Qi, C., ... & Gao, J. (2020). The Deficiency of Maged1 Attenuates Parkinson's Disease Progression by Inhibiting Apoptosis and Enhancing Autophagy in Mice.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

MAGED1 Matched Antibody Pair (708) (CAT#: APMAB-708LY)

MAGED1 Matched Antibody Pair (709) (CAT#: APMAB-709LY)

Antibody Pairs

MAGED1 Matched Antibody Pair (708) (CAT#: APMAB-708LY)

MAGED1 Matched Antibody Pair (709) (CAT#: APMAB-709LY)

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MAGED1 Matched Antibody Pair (708) (CAT#: APMAB-708LY)

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Mouse Anti-MAGED1 (AA 117-226) Recombinant Antibody (CBFYM-1329) (CAT#: CBMAB-M1488-FY)

Isotype control

For research use only. Not intended for any clinical use.

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