MAP3K1

The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]

Full Name

Mitogen-Activated Protein Kinase Kinase Kinase 1

Function

Component of a protein kinase signal transduction cascade (PubMed:9808624).
Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624).
May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173).
Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624).

Biological Process

Cellular response to mechanical stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Fc-epsilon receptor signaling pathwayTAS:Reactome
Protein phosphorylation1 PublicationNAS:UniProtKB

Cellular Location

Cytoplasm
Cytosol

Involvement in disease

46,XY sex reversal 6 (SRXY6):
A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females.

PTM

Autophosphorylated.