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MBL1

Plays a role in the innate immune response by binding mannose, fucose and N-acetylglucosamine moieties on different microorganisms and mediating activation of the lectin complement pathway.

Full Name

Mannose-Binding Lectin (Protein A) 1

Function

Calcium-dependent lectin. Plays a role in the innate immune response by binding mannose, fucose and N-acetylglucosamine moieties on different microorganisms and mediating activation of the lectin complement pathway (By similarity).

Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).

Biological Process

Complement activation, classical pathway Source: UniProtKB-KW
Complement activation, lectin pathway Source: MGI
Defense response to Gram-positive bacterium Source: MGI
Killing by host of symbiont cells Source: MGI
Positive regulation of phagocytosis Source: MGI
Protein homotrimerization Source: UniProtKB
Surfactant homeostasis Source: GO_Central

Cellular Location

Secreted

PTM

Hydroxylated on lysine and proline residues within the collagen-like domain.
O-glycosylated. O-linked glycans on hydroxylysine residues consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.

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Anti-MBL1 antibodies

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Rat Recombinant MBL1 protein, hFc Tag (V2LY-0526-LY9517)

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Target: MBL1

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-238

Tag: hFc Tag

Recombinant Rat Anti-MBL1 Antibody (CBHb024) (CBMAB-Hb740-LY)

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Target: MBL1

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBHb024

Application*: Immuno assays, WB

Recombinant Rat Anti-MBL1 Antibody (CBHb023) (CBMAB-Hb739-LY)

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Target: MBL1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBHb023

Application*: IHC-F, Immuno assays, IF, WB

Rat Anti-MBL1 Recombinant Antibody (CBFYA-0016) (CBMAB-X0024-FY)

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Target: MBL1

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBFYA-0016

Application*: IA, WB

Rat Anti-MBL1 Recombinant Antibody (CBFYA-0015) (CBMAB-X0023-FY)

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Target: MBL1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBFYA-0015

Application*: C, IA, IF, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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