Rat Anti-MBL1 Recombinant Antibody (CBFYA-0015) (CBMAB-X0023-FY)

Name: Rat Anti-MBL1 Recombinant Antibody (CBFYA-0015)
SKU: CBMAB-X0023-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBFYA-0015

Application

IHC-Fr, Immunoassay, IF, WB

Immunogen

Purified mouse MBL-A

Specificity

Mouse

Antibody Isotype

IgG2a

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% BSA

Preservative

0.02% Sodium azide

Concentration

0.1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Mannose-Binding Lectin (Protein A) 1

Introduction

Plays a role in the innate immune response by binding mannose, fucose and N-acetylglucosamine moieties on different microorganisms and mediating activation of the lectin complement pathway.

Entrez Gene ID

17194

UniProt ID

P39039

Alternative Names

MBL-A; MBP-A; S-MBP

Function

Calcium-dependent lectin. Plays a role in the innate immune response by binding mannose, fucose and N-acetylglucosamine moieties on different microorganisms and mediating activation of the lectin complement pathway (By similarity).

Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).

Biological Process

Complement activation, classical pathway Source: UniProtKB-KW
Complement activation, lectin pathway Source: MGI
Defense response to Gram-positive bacterium Source: MGI
Killing by host of symbiont cells Source: MGI
Positive regulation of phagocytosis Source: MGI
Protein homotrimerization Source: UniProtKB
Surfactant homeostasis Source: GO_Central

Cellular Location

Secreted

PTM

Hydroxylated on lysine and proline residues within the collagen-like domain.
O-glycosylated. O-linked glycans on hydroxylysine residues consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.

Ma, L., Haile, Z. M., Sabbadini, S., Mezzetti, B., Negrini, F., & Baraldi, E. (2023). Functional characterization of MANNOSE-BINDING LECTIN 1, a G-type lectin gene family member, in response to fungal pathogens of strawberry. Journal of Experimental Botany, 74(1), 149-161.

Ma, Y., Cai, F., Huang, X., Wang, H., Yu, B., Wang, J., ... & Han, F. (2022). Mannose Binding Lectin Activates the Nuclear Factor-κB and Renal Inflammation in the Progression of Diabetic Nephropathy. Available at SSRN 3965383.

Kalia, N., Singh, J., & Kaur, M. (2021). The ambiguous role of mannose-binding lectin (MBL) in human immunity. Open Medicine, 16(1), 299-310.

Neglia, L., Oggioni, M., Mercurio, D., De Simoni, M. G., & Fumagalli, S. (2020). Specific contribution of mannose-binding lectin murine isoforms to brain ischemia/reperfusion injury. Cellular & Molecular Immunology, 17(3), 218-226.

Jacobson, S., Larsson, P., Åberg, A. M., Johansson, G., Winsö, O., & Söderberg, S. (2020). Levels of mannose-binding lectin (MBL) associates with sepsis-related in-hospital mortality in women. Journal of inflammation, 17, 1-11.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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