ME3

Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

MALIC ENZYME 3

Catalyzes the oxidative decarboxylation of (S)-malate to pyruvate using NADP+ as a cofactor (PubMed:7818469).

Can also reverse the decarboxylation reaction, but only with significantly lower efficiency (PubMed:7818469).

Aerobic respiration Source: UniProtKB
Malate metabolic process Source: UniProtKB
Oxygen metabolic process Source: UniProtKB
Pyruvate metabolic process Source: UniProtKB

Mitochondrion matrix