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MED6

MED6 (Mediator Complex Subunit 6) is a Protein Coding gene. Among its related pathways are Gene Expression and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to this gene include transcription factor binding and RNA polymerase II transcription cofactor activity.

Full Name

Mediator Complex Subunit 6

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Biological Process

Positive regulation of transcription by RNA polymerase II Source: MGI
Positive regulation of transcription elongation from RNA polymerase II promoter Source: ComplexPortal
Positive regulation of transcription initiation from RNA polymerase II promoter Source: ComplexPortal
Regulation of transcription by RNA polymerase II Source: GO_Central
RNA polymerase II preinitiation complex assembly Source: ComplexPortal
Stem cell population maintenance Source: Ensembl

Cellular Location

Nucleus

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Anti-MED6 antibodies

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Mouse Anti-MED6 Antibody (3D10) (CBMAB-0651-YC)

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Target: MED6

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 3D10

Application*: IP, M

MED6 Matched Antibody Pair (731) (APMAB-731LY)

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Target: MED6

Specificity: Human

MED6 Matched Antibody Pair (730) (APMAB-730LY)

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Target: MED6

Specificity: Human

MED6 Matched Antibody Pair (729) (APMAB-729LY)

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Target: MED6

Specificity: Human

Mouse Anti-MED6 Recombinant Antibody (4C2) (CBMAB-A5378-LY)

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Target: MED6

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 4C2

Application*: WB, E

Mouse Anti-MED6 (AA 1-247) Recombinant Antibody (CBFYM-2014) (CBMAB-M2192-FY)

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Target: MED6

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYM-2014

Application*: WB

Mouse Anti-MED6 Recombinant Antibody (CBFYM-2013) (CBMAB-M2191-FY)

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Target: MED6

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYM-2013

Application*: E, WB

Mouse Anti-MED6 Recombinant Antibody (CBFYM-2012) (CBMAB-M2190-FY)

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Target: MED6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-2012

Application*: WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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