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MEOX2

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq]

Full Name

mesenchyme homeobox 2

Function

Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation (By similarity).

Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (By similarity).

May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity).

Also acts as a negative regulator of angiogenesis (PubMed:17074759, PubMed:20516212, PubMed:22206000).

Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation (PubMed:17074759, PubMed:22206000).

While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000).

Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (By similarity).

Biological Process

Angiogenesis Source: Ensembl
Blood circulation Source: ProtInc
Limb development Source: Ensembl
Multicellular organism development Source: ProtInc
Negative regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Roof of mouth development Source: Ensembl
Skeletal muscle tissue development Source: Ensembl
Somite development Source: GO_Central
Somite specification Source: Ensembl

Cellular Location

Nucleus
Nucleus speckle

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Anti-MEOX2 antibodies

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Mouse Anti-MEOX2 Recombinant Antibody (4D3) (CBMAB-A5430-LY)

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Target: MEOX2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4D3

Application*: WB, E

Mouse Anti-MEOX2 Recombinant Antibody (4B2) (CBMAB-A5429-LY)

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Target: MEOX2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: 4B2

Application*: WB, E

Mouse Anti-MEOX2 Recombinant Antibody (CBFYM-2073) (CBMAB-M2254-FY)

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Target: MEOX2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Rat, Human

Clone: CBFYM-2073

Application*: WB, P, IF, SE

Mouse Anti-MEOX2 (AA 1-304) Recombinant Antibody (CBFYM-2072) (CBMAB-M2253-FY)

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Target: MEOX2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-2072

Application*: IF, WB

Mouse Anti-MEOX2 (AA 1-110) Recombinant Antibody (CBFYM-2071) (CBMAB-M2252-FY)

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Target: MEOX2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYM-2071

Application*: E, WB

Mouse Anti-MEOX2 Recombinant Antibody (CBLG1-2388) (CBMAB-G6380-LY)

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Target: MEOX2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: CBLG1-2388

Application*: E, IF, P, WB

Mouse Anti-MEOX2 Recombinant Antibody (CBLG1-2387) (CBMAB-G6379-LY)

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Target: MEOX2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-2387

Application*: E, IF, WB

Mouse Anti-MEOX2 Recombinant Antibody (CBLG1-2386) (CBMAB-G6378-LY)

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Target: MEOX2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: CBLG1-2386

Application*: E, WB

Rabbit Anti-MEOX2 Recombinant Antibody (CBLG1-3085) (CBMAB-G6377-LY)

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Target: MEOX2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-3085

Application*: F

Mouse Anti-MEOX2 Recombinant Antibody (6A5) (CBMAB-G6376-LY)

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Target: MEOX2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 6A5

Application*: E, IF, P, WB

Mouse Anti-MEOX2 Recombinant Antibody (4F6) (CBMAB-G6375-LY)

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Target: MEOX2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4F6

Application*: WB

Mouse Anti-MEOX2 Recombinant Antibody (CBLG1-315) (CBMAB-G1146-LY)

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Target: MEOX2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-315

Application*: E, IC, WB

More Infomation

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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