MEOX2

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq]

mesenchyme homeobox 2

Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation (By similarity).

Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (By similarity).

May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity).

Also acts as a negative regulator of angiogenesis (PubMed:17074759, PubMed:20516212, PubMed:22206000).

Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation (PubMed:17074759, PubMed:22206000).

While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000).

Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (By similarity).

Angiogenesis Source: Ensembl
Blood circulation Source: ProtInc
Limb development Source: Ensembl
Multicellular organism development Source: ProtInc
Negative regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Roof of mouth development Source: Ensembl
Skeletal muscle tissue development Source: Ensembl
Somite development Source: GO_Central
Somite specification Source: Ensembl

Nucleus
Nucleus speckle