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Mouse Anti-MEOX2 Recombinant Antibody (4B2) (CBMAB-A5429-LY)

The product is antibody recognizes MEOX2. The antibody 4B2 immunoassay techniques such as: WB, ELISA.
See all MEOX2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
4B2
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
MEOX2 (AAH17021, 1 a.a. ~ 303 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
mesenchyme homeobox 2
Introduction
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq]
Entrez Gene ID
Human4223
Mouse17286
Rat29279
UniProt ID
HumanP50222
MouseP32443
RatP39020
Alternative Names
GAX; MOX2
Function
Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation (By similarity).

Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (By similarity).

May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity).

Also acts as a negative regulator of angiogenesis (PubMed:17074759, PubMed:20516212, PubMed:22206000).

Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation (PubMed:17074759, PubMed:22206000).

While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000).

Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (By similarity).
Biological Process
Angiogenesis Source: Ensembl
Blood circulation Source: ProtInc
Limb development Source: Ensembl
Multicellular organism development Source: ProtInc
Negative regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Roof of mouth development Source: Ensembl
Skeletal muscle tissue development Source: Ensembl
Somite development Source: GO_Central
Somite specification Source: Ensembl
Cellular Location
Nucleus
Nucleus speckle

Shi, H., Duan, L., Lan, Y., He, Q., Pu, P., & Tang, H. (2023). RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate Pirarubicin-Induced Cardiomyocyte Apoptosis. Oxidative Medicine and Cellular Longevity, 2023.

Duan, L., Tang, H., Lan, Y., Shi, H., Pu, P., & He, Q. (2023). Ring finger protein 10 improves pirarubicin-induced cardiac inflammation by regulating the AP-1/Meox2 signaling pathway. Toxicology and Applied Pharmacology, 462, 116411.

Schönrock, A., Heinzelmann, E., Steffl, B., Demirdizen, E., Narayanan, A., Krunic, D., ... & Turcan, Ş. (2022). MEOX2 homeobox gene promotes growth of malignant gliomas. Neuro-oncology, 24(11), 1911-1924.

Kokotović, T., Lenartowicz, E. M., Langeslag, M., Ciotu, C. I., Fell, C. W., Scaramuzza, A., ... & Nagy, V. (2022). Transcription factor mesenchyme homeobox protein 2 (MEOX2) modulates nociceptor function. The FEBS Journal, 289(12), 3457-3476.

Chen, J., Li, H., Zhang, B., Xiong, Z., Jin, Z., Chen, J., ... & Zhang, S. (2022). ABI2‐mediated MEOX2/KLF4‐NANOG axis promotes liver cancer stem cell and drives tumour recurrence. Liver International, 42(11), 2562.

Peralta-Arrieta, I., Trejo-Villegas, O. A., Armas-Lopez, L., Ceja-Rangel, H. A., del Carmen Ordóñez-Luna, M., Pineda-Villegas, P., ... & Avila-Moreno, F. (2022). Failure to EGFR-TKI-based therapy and tumoural progression are promoted by MEOX2/GLI1-mediated epigenetic regulation of EGFR in the human lung cancer. European Journal of Cancer, 160, 189-205.

Tachon, G., Masliantsev, K., Rivet, P., Desette, A., Milin, S., Gueret, E., ... & Guichet, P. O. (2021). MEOX2 transcription factor is involved in survival and adhesion of glioma stem-like cells. Cancers, 13(23), 5943.

Huang, Y., Liang, B., & Chen, X. (2021). Exosomal circular RNA circ_0074673 regulates the proliferation, migration, and angiogenesis of human umbilical vein endothelial cells via the microRNA-1200/MEOX2 axis. Bioengineered, 12(1), 6782-6792.

Yin, H., He, H., Cao, X., Shen, X., Han, S., Cui, C., ... & Zhu, Q. (2020). MiR-148a-3p regulates skeletal muscle satellite cell differentiation and apoptosis via the PI3K/AKT signaling pathway by targeting Meox2. Frontiers in Genetics, 11, 512.

Tachon, G., Masliantsev, K., Rivet, P., Petropoulos, C., Godet, J., Milin, S., ... & Karayan-Tapon, L. (2019). Prognostic significance of MEOX2 in gliomas. Modern Pathology, 32(6), 774-786.

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For research use only. Not intended for any clinical use.

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