MGAT1

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene.

Full Name

MANNOSYL (ALPHA-1,3-)-GLYCOPROTEIN BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE

Function

Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.

Biological Process

In utero embryonic development Source: Ensembl
Protein glycosylation Source: GO_Central
Protein N-linked glycosylation Source: GO_Central
Protein N-linked glycosylation via asparagine Source: UniProtKB
UDP-N-acetylglucosamine catabolic process Source: Ensembl
Viral protein processing Source: Reactome

Cellular Location

Golgi apparatus
Golgi apparatus membrane
Other locations
perinuclear region
Note: Co-localizes with BRI3 isoform 1 at the perinuclear region.

Topology

Cytoplasmic: 1-6
Helical: 7-29
Lumenal: 30-445