MIA2

This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low density lipoproteins (pre-VLDLs). Three major classes of transcripts are generated from this gene-melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species (TANGO1-like or TALI). Additionally, alternative splicing in these transcripts results in multiple transcript variants encoding multiple isoforms.

melanoma inhibitory activity 2

Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:27138255, PubMed:21525241, PubMed:25202031, PubMed:27170179).

Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255).

Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity).

Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179).

Endoplasmic reticulum to Golgi vesicle-mediated transport Source: UniProtKB
Lipoprotein transport Source: UniProtKB
Protein exit from endoplasmic reticulum Source: UniProtKB
Protein localization to endoplasmic reticulum exit site Source: UniProtKB
Protein secretion Source: GO_Central
Vesicle cargo loading Source: UniProtKB

Endoplasmic reticulum
Endoplasmic reticulum membrane
Note: Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER).

Autoantibodies against MIA2 are present in several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL).