Mouse Anti-MIA2 (AA 448-553) Recombinant Antibody (CBFYM-2198) (CBMAB-M2381-FY)

Name: Mouse Anti-MIA2 (AA 448-553) Recombinant Antibody (CBFYM-2198)
SKU: CBMAB-M2381-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBFYM-2198

Application

ELISA, WB

Immunogen

Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: TDESDTIPYL KKFLYNFDNP WNFQNIPKET ELPFPKQILD QNNVIENEET GEFSIDNYPT DNTKVMIFKS SYSLSDMVSN IELPTRIHEE VYFEPSSSKD SDENSK

Specificity

Human

Antibody Isotype

IgG2a, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 448-553

More Infomation

Target

Full Name

melanoma inhibitory activity 2

Introduction

This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low density lipoproteins. Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species. Additionally, alternative splicing in these transcripts results in multiple transcript variants encoding multiple isoforms.

Entrez Gene ID

4253

UniProt ID

Q96PC5

Alternative Names

Melanoma Inhibitory Activity 2; CTAGE Family Member 5, ER Export Factor; CTAGE5; Meningioma Expressed Antigen 6 (Coiled-Coil Proline-Rich); Cutaneous T-Cell Lymphoma-Associated Antigen 5; Melanoma Inhibitory Activity Protein 2; Meningioma-Expressed Antigen 6/11; CTAGE Family, Member 5

Function

Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:27138255, PubMed:21525241, PubMed:25202031, PubMed:27170179).

Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255).

Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity).

Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179).

Biological Process

Endoplasmic reticulum to Golgi vesicle-mediated transport Source: UniProtKB
Lipoprotein transport Source: UniProtKB
Protein exit from endoplasmic reticulum Source: UniProtKB
Protein localization to endoplasmic reticulum exit site Source: UniProtKB
Protein secretion Source: GO_Central
Vesicle cargo loading Source: UniProtKB

Cellular Location

Endoplasmic reticulum
Endoplasmic reticulum membrane
Note: Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER).

Involvement in disease

Autoantibodies against MIA2 are present in several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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