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Mouse Anti-MIA2 (AA 448-553) Recombinant Antibody (CBFYM-2198) (CBMAB-M2381-FY)

This product is mouse antibody that recognizes MIA2. The antibody CBFYM-2198 can be used for immunoassay techniques such as: ELISA, WB.
See all MIA2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2198
Antibody Isotype
IgG2a, k
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: TDESDTIPYL KKFLYNFDNP WNFQNIPKET ELPFPKQILD QNNVIENEET GEFSIDNYPT DNTKVMIFKS SYSLSDMVSN IELPTRIHEE VYFEPSSSKD SDENSK
Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 448-553

Target

Full Name
melanoma inhibitory activity 2
Introduction
This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low density lipoproteins. Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species. Additionally, alternative splicing in these transcripts results in multiple transcript variants encoding multiple isoforms.
Entrez Gene ID
4253
UniProt ID
Q96PC5
Alternative Names
Melanoma Inhibitory Activity 2; CTAGE Family Member 5, ER Export Factor; CTAGE5; Meningioma Expressed Antigen 6 (Coiled-Coil Proline-Rich); Cutaneous T-Cell Lymphoma-Associated Antigen 5; Melanoma Inhibitory Activity Protein 2; Meningioma-Expressed Antigen 6/11; CTAGE Family, Member 5
Function
Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:27138255, PubMed:21525241, PubMed:25202031, PubMed:27170179).

Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255).

Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity).

Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179).
Biological Process
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: UniProtKB
Lipoprotein transport Source: UniProtKB
Protein exit from endoplasmic reticulum Source: UniProtKB
Protein localization to endoplasmic reticulum exit site Source: UniProtKB
Protein secretion Source: GO_Central
Vesicle cargo loading Source: UniProtKB
Cellular Location
Endoplasmic reticulum
Endoplasmic reticulum membrane
Note: Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER).
Involvement in disease
Autoantibodies against MIA2 are present in several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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