MPI

Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Full Name
Mannose Phosphate Isomerase
Function
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Biological Process
GDP-mannose biosynthetic process Source: GO_Central
Mannose to fructose-6-phosphate metabolic process Source: Ensembl
Cellular Location
Cytoplasm
Involvement in disease
Congenital disorder of glycosylation 1B (CDG1B):
A form of congenital disorder of glycosylation, a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. CDG1B is clinically characterized by protein-losing enteropathy.
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Anti-MPI antibodies

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Mouse Anti-MPI Recombinant Antibody (A1168) (CBMAB-AP12277LY)

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Target: MPI
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: A1168
Application*: ICC, WB
Datasheet SDS

Mouse Anti-MPI Recombinant Antibody (A1167) (CBMAB-AP4855LY)

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Target: MPI
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A1167
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-MPI Recombinant Antibody (A1166) (CBMAB-AP4853LY)

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Target: MPI
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A1166
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-MPI Recombinant Antibody (CB429A) (CBMAB-CA429LY)

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Target: MPI
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CB429A
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-MPI Recombinant Antibody (11I4) (CBMAB-BR357LY)

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Target: MPI
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11I4
Application*: FC, WB
Datasheet SDS

Mouse Anti-MPI Recombinant Antibody (CBFYM-2493) (CBMAB-M2680-FY)

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Target: MPI
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBFYM-2493
Application*: IC, WB
Datasheet SDS

Mouse Anti-MPI Recombinant Antibody (CBFYM-2492) (CBMAB-M2679-FY)

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Target: MPI
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBFYM-2492
Application*: E, WB
Datasheet SDS

Mouse Anti-MPI Recombinant Antibody (CBFYM-2491) (CBMAB-M2678-FY)

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Target: MPI
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2491
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-MPI Recombinant Antibody (
28F3) (V2LY-0725-LY539)

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Target: MPI
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 28F3
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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