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Mouse Anti-MPI Recombinant Antibody (A1167) (CBMAB-AP4855LY)

The product is antibody recognizes MPI. The antibody A1167 immunoassay techniques such as: ELISA, WB.
See all MPI antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
A1167
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Mannose Phosphate Isomerase
Introduction
Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Entrez Gene ID
Human4351
Mouse110119
Rat300741
UniProt ID
HumanP34949
MouseQ924M7
RatQ68FX1
Alternative Names
Mannose Phosphate Isomerase; Mannose-6-Phosphate Isomerase; Phosphohexomutase; EC 5.3.1.8; PMI1; PMI;
Function
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Biological Process
GDP-mannose biosynthetic process Source: GO_Central
Mannose to fructose-6-phosphate metabolic process Source: Ensembl
Cellular Location
Cytoplasm
Involvement in disease
Congenital disorder of glycosylation 1B (CDG1B):
A form of congenital disorder of glycosylation, a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. CDG1B is clinically characterized by protein-losing enteropathy.

Lu, S., Liang, S., Wu, Y., Liu, J., Lin, L., Huang, G., & Ning, H. (2023). Mannose phosphate isomerase gene mutation leads to a congenital disorder of glycosylation: A rare case report and literature review. Frontiers in Pediatrics, 11, 1150367.

De Graef, D., Mousa, J., Waberski, M. B., & Morava, E. (2022). Mannose treatment improves immune deficiency in mannose phosphate isomerase–congenital disorder of glycosylation: case report and review of literature. Therapeutic Advances in Rare Disease, 3, 26330040221091283.

Luo, H., Wang, X., Wang, Y., Dan, Q., & Ge, H. (2022). Mannose enhances the radio-sensitivity of esophageal squamous cell carcinoma with low MPI expression by suppressing glycolysis. Discover Oncology, 13(1), 1.

Li, Z., Liu, X., Nakanishi, H., & Gao, X. D. (2020). Encapsulation of mannose-6-phosphate isomerase in yeast spores and its application in L-ribose production. Journal of Agricultural and Food Chemistry, 68(25), 6892-6899.

Kim, S. J., Kim, Y. S., & Yeom, S. J. (2020). Phosphate sugar isomerases and their potential for rare sugar bioconversion. Journal of Microbiology, 58, 725-733.

Čechová, A., Altassan, R., Borgel, D., Bruneel, A., Correia, J., Girard, M., ... & Honzík, T. (2020). Consensus guideline for the diagnosis and management of mannose phosphate isomerase‐congenital disorder of glycosylation. Journal of inherited metabolic disease, 43(4), 671-693.

Mühlhausen, C., Henneke, L., Schlotawa, L., Behme, D., Grüneberg, M., Gärtner, J., & Marquardt, T. (2020). Mannose phosphate isomerase deficiency‐congenital disorder of glycosylation (MPI‐CDG) with cerebral venous sinus thrombosis as first and only presenting symptom: A rare but treatable cause of thrombophilia. JIMD reports, 55(1), 38-43.

Noman, K., Hendriksz, C. J., Radcliffe, G., Roncaroli, F., Moreea, S., Hussain, A., & Stepien, K. M. (2020). Clinical outcomes in an adult patient with mannose phosphate isomerase-congenital disorder of glycosylation who discontinued mannose therapy. Molecular Genetics and Metabolism Reports, 25, 100646.

DeRossi, C., Bambino, K., Morrison, J., Sakarin, I., Villacorta‐Martin, C., Zhang, C., ... & Chu, J. (2019). Mannose phosphate isomerase and mannose regulate hepatic stellate cell activation and fibrosis in zebrafish and humans. Hepatology, 70(6), 2107-2122.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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