MRS2

MRS2 (MRS2, Magnesium Transporter) is a Protein Coding gene. Diseases associated with MRS2 include Basilar Artery Occlusion. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Miscellaneous transport and binding events. Gene Ontology (GO) annotations related to this gene include magnesium ion transmembrane transporter activity.

Full Name

MRS2, MAGNESIUM TRANSPORTER

Function

Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665).

Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665).

Biological Process

Magnesium ion transport Source: GO_Central
Mitochondrial magnesium ion transmembrane transport Source: UniProtKB
Transmembrane transport Source: Reactome

Cellular Location

Mitochondrion

Involvement in disease

Mitochondrion inner membrane

Topology

Mitochondrial matrix: 50-339
Helical: 340-360
Mitochondrial intermembrane: 361-372
Helical: 373-393
Mitochondrial matrix: 394-443