Mouse Anti-MRS2 Recombinant Antibody (CBFYH-2656) (CBMAB-H0586-FY)

Name: Mouse Anti-MRS2 Recombinant Antibody (CBFYH-2656)
SKU: CBMAB-H0586-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-2656

Application

ELISA

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MRS2, MAGNESIUM TRANSPORTER

Introduction

MRS2 (MRS2, Magnesium Transporter) is a Protein Coding gene. Diseases associated with MRS2 include Basilar Artery Occlusion. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Miscellaneous transport and binding events. Gene Ontology (GO) annotations related to this gene include magnesium ion transmembrane transporter activity.

Entrez Gene ID

57380

UniProt ID

Q9HD23

Alternative Names

MRS2, Magnesium Transporter; MRS2-Like Protein; MRS2L; HPT; MRS2 Magnesium Homeostasis Factor Homolog (S. Cerevisiae); MRS2-Like, Magnesium Homeostasis Factor (S. Cerevisiae); Magnesium Transporter MRS2 Homolog, Mitochondrial; MRS2-Like, Magnesium Homeostasis Factor; Putative Magnesium Transporter

Function

Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665).

Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665).

Biological Process

Magnesium ion transport Source: GO_Central
Mitochondrial magnesium ion transmembrane transport Source: UniProtKB
Transmembrane transport Source: Reactome

Cellular Location

Mitochondrion

Involvement in disease

Mitochondrion inner membrane

Topology

Mitochondrial matrix: 50-339
Helical: 340-360
Mitochondrial intermembrane: 361-372
Helical: 373-393
Mitochondrial matrix: 394-443

Lai, L. T. F., Balaraman, J., Zhou, F., & Matthies, D. (2023). Cryo-EM structures of human magnesium channel MRS2 reveal gating and regulatory mechanisms. Nature Communications, 14(1), 7207.

Liu, W., Khan, S., Tong, M., Hu, H., Yin, L., & Huang, J. (2023). Identification and Expression of the CorA/MRS2/ALR Type Magnesium Transporters in Tomato. Plants, 12(13), 2512.

Uthayabalan, S., Vishnu, N., Madesh, M., & Stathopulos, P. B. (2023). The human MRS2 magnesium-binding domain is a regulatory feedback switch for channel activity. Life Science Alliance, 6(4).

Joshi, A., & Gohil, V. M. (2023). Cardiolipin deficiency leads to the destabilization of mitochondrial magnesium channel MRS2 in Barth syndrome. Human Molecular Genetics, 32(24), 3353-3360.

Madaris, T. R., Venkatesan, M., Maity, S., Stein, M. C., Vishnu, N., Venkateswaran, M. K., ... & Madesh, M. (2023). Limiting Mrs2-dependent mitochondrial Mg2+ uptake induces metabolic programming in prolonged dietary stress. Cell reports, 42(3).

Li, M., Li, Y., Lu, Y., Li, J., Lu, X., Ren, Y., ... & Shen, Y. (2023). Molecular basis of Mg2+ permeation through the human mitochondrial Mrs2 channel. Nature communications, 14(1), 4713.

Ishijima, S., Shiomi, R., & Sagami, I. (2021). Functional analysis of whether the glycine residue of the GMN motif of the Arabidopsis MRS2/MGT/CorA-type Mg2+ channel protein AtMRS2-11 is critical for Mg2+ transport activity. Archives of Biochemistry and Biophysics, 697, 108673.

Tong, M., Liu, W., He, H., Hu, H., Ding, Y., Li, X., ... & Yin, L. (2020). Identification and functional analysis of the CorA/MGT/MRS2-type magnesium transporter in banana. Plos one, 15(10), e0239058.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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