MYH10

This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Full Name

Myosin Heavy Chain 10

Function

Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9.

Biological Process

Actin filament-based movement Source: MGI
Actomyosin structure organization Source: UniProtKB
Cell adhesion Source: UniProtKB-KW
Mitotic cytokinesis Source: MGI
Positive regulation of protein secretion Source: UniProtKB
Regulation of cell shape Source: UniProtKB-KW

Cellular Location

Other locations
lamellipodium
Note: Colocalizes with MCC at the leading edge of migrating cells.

Involvement in disease

Associated with severe intellectual disability, microcephaly, and feeding difficulties as well as cerebral atrophy.

PTM

Phosphorylated by ABL2.