Mouse Anti-MYH10 Recombinant Antibody (CBFYM-0031) (CBMAB-M0036-FY)

Name: Mouse Anti-MYH10 Recombinant Antibody (CBFYM-0031)
SKU: CBMAB-M0036-FY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-0031

Application

Basic Information

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 50% glycerol

Preservative

0.02% Sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Myosin Heavy Chain 10

Introduction

This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10. Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

4628

UniProt ID

P35580

Alternative Names

Myosin Heavy Chain 10; Myosin, Heavy Polypeptide 10, Non-Muscle; Cellular Myosin Heavy Chain, Type B; NMMHC-IIB; Myosin Heavy Chain, Nonmuscle Type B; Myosin, Heavy Chain 10, Non-Muscle; Myosin Heavy Chain, Non-Muscle IIb; Nonmuscle Myosin II Heavy Chain-B

Function

Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9.

Biological Process

Actin filament-based movement Source: MGI
Actomyosin structure organization Source: UniProtKB
Cell adhesion Source: UniProtKB-KW
Mitotic cytokinesis Source: MGI
Positive regulation of protein secretion Source: UniProtKB
Regulation of cell shape Source: UniProtKB-KW

Cellular Location

Other locations
lamellipodium
Note: Colocalizes with MCC at the leading edge of migrating cells.

Involvement in disease

Associated with severe intellectual disability, microcephaly, and feeding difficulties as well as cerebral atrophy.

PTM

Phosphorylated by ABL2.

More Infomation

References

Jun, Y. W., Lee, S., Ban, B. K., Lee, J. A., & Gao, F. B. (2023). Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis. Autophagy, 1-17.

Meng, L. B., Li, J. Y., Xu, H. X., Wu, D. S., Shan, M. J., Chen, Y. H., ... & Liu, D. P. (2022). A potential biomarker for clinical atherosclerosis: A novel insight derived from myosin heavy chain 10 promoting transformation of vascular smooth muscle cells. Clinical and Translational Medicine, 12(1), e672.

Lv, Y., Chen, J., Hu, J., Qian, Y., Kong, Y., & Fu, L. (2020). Nonmuscle myosin heavy chain ⅡA-mediated exosome release via regulation of the rho-associated kinase 1/myosin light chains/actin pathway. Frontiers in Pharmacology, 11, 598592.

López-Unzu, M. A., Durán, A. C., Soto-Navarrete, M. T., Sans-Coma, V., & Fernández, B. (2019). Differential expression of myosin heavy chain isoforms in cardiac segments of gnathostome vertebrates and its evolutionary implications. Frontiers in zoology, 16(1), 1-15.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-MYH10 Recombinant Antibody (3H2)

Rabbit Anti-MYH10 Recombinant Antibody (CBFYM-2918)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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