NABP2

Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).

Full Name

nucleic acid binding protein 2

Function

Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

Biological Process

Cellular response to DNA damage stimulus Source: UniProtKB
DNA repair Source: UniProtKB
Double-strand break repair via homologous recombination Source: ComplexPortal
Establishment of protein localization to telomere Source: BHF-UCL
Mitotic G2/M transition checkpoint Source: ComplexPortal
Positive regulation of telomere capping Source: BHF-UCL
Response to ionizing radiation Source: UniProtKB

Cellular Location

Nucleus
Note: Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment.

PTM

Phosphorylated by ATM in response to DNA damage. Phosphorylation prevents degradation by the proteasome, hence stabilization of the protein and accumulation within cells.