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Mouse Anti-NABP2 Recombinant Antibody (1E11) (CBMAB-O0233-CQ)

This product is a mouse antibody that recognizes NABP2. The antibody 1E11 can be used for immunoassay techniques such as: WB, FC, IHC, IHC-P.
See all NABP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E11
Antibody Isotype
IgG1
Application
WB, FC, IHC, IHC-P

Basic Information

Immunogen
Full length human Recombinant protein of human OBFC2B(NP_076973) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nucleic acid binding protein 2
Introduction
Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage.
Entrez Gene ID
79035
UniProt ID
Q9BQ15
Alternative Names
Nucleic Acid Binding Protein 2; Sensor Of Single-Strand DNA Complex Subunit B1; Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 2B; Oligonucleotide/Oligosaccharide-Binding Fold Containing 2B; Single-Stranded DNA-Binding Protein 1; Single Strand DNA-Binding Protein 1; Sensor Of SsDNA Subunit B1; SOSS-B1
Function
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
Biological Process
Cellular response to DNA damage stimulus Source: UniProtKB
DNA repair Source: UniProtKB
Double-strand break repair via homologous recombination Source: ComplexPortal
Establishment of protein localization to telomere Source: BHF-UCL
Mitotic G2/M transition checkpoint Source: ComplexPortal
Positive regulation of telomere capping Source: BHF-UCL
Response to ionizing radiation Source: UniProtKB
Cellular Location
Nucleus
Note: Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment.
PTM
Phosphorylated by ATM in response to DNA damage. Phosphorylation prevents degradation by the proteasome, hence stabilization of the protein and accumulation within cells.

Peng, H., Cai, S., Chen, R., Tan, L., Lu, S., Lu, X., ... & Peng, X. (2023). NABP2 as an oncogenic biomarker promotes hepatocellular carcinoma progression and metastasis. American Journal of Translational Research, 15(6), 4203.

Adams, M. N., Croft, L. V., Urquhart, A., Saleem, M. A. M., Rockstroh, A., Duijf, P. H., ... & Richard, D. J. (2023). hSSB1 (NABP2/OBFC2B) modulates the DNA damage and androgen‐induced transcriptional response in prostate cancer. The Prostate, 83(7), 628-640.

Li, B., Liu, J., Xu, L., Xu, Q., Liu, Z., & Liu, T. (2023). Comprehensive Analysis of NABP2 as a Prognostic Biomarker and Its Correlation with Immune Infiltration in Hepatocellular Carcinoma. Journal of Inflammation Research, 1783-1804.

Lin, E., Tsai, S. J., Kuo, P. H., Liu, Y. L., Yang, A. C., Conomos, M. P., & Thornton, T. A. (2021). Genome-wide association study in the Taiwan Biobank identifies four novel genes for human height: NABP2, RA SA2, RNF41 and SLC39A5. Human Molecular Genetics, 30(23), 2362-2369.

El-Kamand, S., Du Plessis, M. D., Lawson, T., Cubeddu, L., & Gamsjaeger, R. (2021). Expression, purification, and solution-state NMR analysis of the two human single-stranded DNA-binding proteins hSSB1 (NABP2/OBFC2B) and hSSB2 (NAPB1/OBFC2A). Single Stranded DNA Binding Proteins, 229-240.

El-Kamand, S., Jergic, S., Lawson, T., Kariawasam, R., Richard, D. J., Cubeddu, L., & Gamsjaeger, R. (2020). A biophysical and structural analysis of DNA binding by oligomeric hSSB1 (NABP2/OBFC2B). BioRxiv, 2020-08.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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