Mouse Anti-NABP2 Recombinant Antibody (1E11) (CBMAB-O0233-CQ)

Name: Mouse Anti-NABP2 Recombinant Antibody (1E11)
SKU: CBMAB-O0233-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1E11

Application

WB, FC, IHC, IHC-P

Immunogen

Full length human Recombinant protein of human OBFC2B(NP_076973) produced in HEK293T cell

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

nucleic acid binding protein 2

Introduction

Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage.

Entrez Gene ID

79035

UniProt ID

Q9BQ15

Alternative Names

Nucleic Acid Binding Protein 2; Sensor Of Single-Strand DNA Complex Subunit B1; Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 2B; Oligonucleotide/Oligosaccharide-Binding Fold Containing 2B; Single-Stranded DNA-Binding Protein 1; Single Strand DNA-Binding Protein 1; Sensor Of SsDNA Subunit B1; SOSS-B1

Function

Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

Biological Process

Cellular response to DNA damage stimulus Source: UniProtKB
DNA repair Source: UniProtKB
Double-strand break repair via homologous recombination Source: ComplexPortal
Establishment of protein localization to telomere Source: BHF-UCL
Mitotic G2/M transition checkpoint Source: ComplexPortal
Positive regulation of telomere capping Source: BHF-UCL
Response to ionizing radiation Source: UniProtKB

Cellular Location

Nucleus
Note: Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment.

PTM

Phosphorylated by ATM in response to DNA damage. Phosphorylation prevents degradation by the proteasome, hence stabilization of the protein and accumulation within cells.

Peng, H., Cai, S., Chen, R., Tan, L., Lu, S., Lu, X., ... & Peng, X. (2023). NABP2 as an oncogenic biomarker promotes hepatocellular carcinoma progression and metastasis. American Journal of Translational Research, 15(6), 4203.

Adams, M. N., Croft, L. V., Urquhart, A., Saleem, M. A. M., Rockstroh, A., Duijf, P. H., ... & Richard, D. J. (2023). hSSB1 (NABP2/OBFC2B) modulates the DNA damage and androgen‐induced transcriptional response in prostate cancer. The Prostate, 83(7), 628-640.

Li, B., Liu, J., Xu, L., Xu, Q., Liu, Z., & Liu, T. (2023). Comprehensive Analysis of NABP2 as a Prognostic Biomarker and Its Correlation with Immune Infiltration in Hepatocellular Carcinoma. Journal of Inflammation Research, 1783-1804.

Lin, E., Tsai, S. J., Kuo, P. H., Liu, Y. L., Yang, A. C., Conomos, M. P., & Thornton, T. A. (2021). Genome-wide association study in the Taiwan Biobank identifies four novel genes for human height: NABP2, RA SA2, RNF41 and SLC39A5. Human Molecular Genetics, 30(23), 2362-2369.

El-Kamand, S., Du Plessis, M. D., Lawson, T., Cubeddu, L., & Gamsjaeger, R. (2021). Expression, purification, and solution-state NMR analysis of the two human single-stranded DNA-binding proteins hSSB1 (NABP2/OBFC2B) and hSSB2 (NAPB1/OBFC2A). Single Stranded DNA Binding Proteins, 229-240.

El-Kamand, S., Jergic, S., Lawson, T., Kariawasam, R., Richard, D. J., Cubeddu, L., & Gamsjaeger, R. (2020). A biophysical and structural analysis of DNA binding by oligomeric hSSB1 (NABP2/OBFC2B). BioRxiv, 2020-08.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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