NAT8B

The protein encoded by this gene is highly similar to the N-acetyltransferase 8 (NAT8) gene product, which is a kidney and liver protein with homology to bacterial acetyltransferases involved in drug resistance. This gene is localized on chromosome 2 in the vicinity of the NAT8 gene and may represent a pseudogene of NAT8. This gene contains two polymorphic nonsense mutations that disrupt the active site of the protein. The full-length product of this gene contains a complete acetyltransferase domain and is identical in length to NAT8. [provided by RefSeq]

Full Name

N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene)

Function

May have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617).

May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241).

Biological Process

Amyloid-beta metabolic process Source: UniProtKB
Amyloid fibril formation Source: Reactome
Gastrulation with mouth forming second Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Peptidyl-lysine N6-acetylation Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB

Cellular Location

Endoplasmic reticulum
Endoplasmic reticulum membrane
Other locations
Endoplasmic reticulum-Golgi intermediate compartment membrane
Note: Enriched in the Endoplasmic reticulum-Golgi intermediate compartment.

Topology

Cytoplasmic: 1-42
Helical: 43-63
Lumenal: 64-227