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Mouse Anti-NAT8B Recombinant Antibody (3B6) (CBMAB-N1227-WJ)

This product is a Mouse antibody that recognizes NAT8B. The antibody 3B6 can be used for immunoassay techniques such as: ELISA, WB.
See all NAT8B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3B6
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene)
Introduction
The protein encoded by this gene is highly similar to the N-acetyltransferase 8 (NAT8) gene product, which is a kidney and liver protein with homology to bacterial acetyltransferases involved in drug resistance. This gene is localized on chromosome 2 in the vicinity of the NAT8 gene and may represent a pseudogene of NAT8. This gene contains two polymorphic nonsense mutations that disrupt the active site of the protein. The full-length product of this gene contains a complete acetyltransferase domain and is identical in length to NAT8. [provided by RefSeq, Jul 2008]
Entrez Gene ID
51471
UniProt ID
Q9UHF3
Alternative Names
N-Acetyltransferase 8B (Putative, Gene/Pseudogene); N-Acetyltransferase 8B (GCN5-Related, Putative, Gene/Pseudogene); Camello-Like Protein 2; Acetyltransferase 1; ATase1; CML2; N-Acetyltransferase 8B (Gene/Pseudogene); Probable N-Acetyltransferase 8B;
Function
May have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617).

May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241).
Biological Process
Amyloid-beta metabolic process Source: UniProtKB
Amyloid fibril formation Source: Reactome
Gastrulation with mouth forming second Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Peptidyl-lysine N6-acetylation Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Cellular Location
Endoplasmic reticulum
Endoplasmic reticulum membrane
Other locations
Endoplasmic reticulum-Golgi intermediate compartment membrane
Note: Enriched in the Endoplasmic reticulum-Golgi intermediate compartment.
Topology
Cytoplasmic: 1-42
Helical: 43-63
Lumenal: 64-227
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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