Mouse Anti-NAT8B Recombinant Antibody (3B6) (CBMAB-N1227-WJ)

Name: Mouse Anti-NAT8B Recombinant Antibody (3B6)
SKU: CBMAB-N1227-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3B6

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene)

Introduction

The protein encoded by this gene is highly similar to the N-acetyltransferase 8 (NAT8) gene product, which is a kidney and liver protein with homology to bacterial acetyltransferases involved in drug resistance. This gene is localized on chromosome 2 in the vicinity of the NAT8 gene and may represent a pseudogene of NAT8. This gene contains two polymorphic nonsense mutations that disrupt the active site of the protein. The full-length product of this gene contains a complete acetyltransferase domain and is identical in length to NAT8. [provided by RefSeq, Jul 2008]

Entrez Gene ID

51471

UniProt ID

Q9UHF3

Alternative Names

N-Acetyltransferase 8B (Putative, Gene/Pseudogene); N-Acetyltransferase 8B (GCN5-Related, Putative, Gene/Pseudogene); Camello-Like Protein 2; Acetyltransferase 1; ATase1; CML2; N-Acetyltransferase 8B (Gene/Pseudogene); Probable N-Acetyltransferase 8B;

Function

May have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617).

May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241).

Biological Process

Amyloid-beta metabolic process Source: UniProtKB
Amyloid fibril formation Source: Reactome
Gastrulation with mouth forming second Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Peptidyl-lysine N6-acetylation Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB

Cellular Location

Endoplasmic reticulum
Endoplasmic reticulum membrane
Other locations
Endoplasmic reticulum-Golgi intermediate compartment membrane
Note: Enriched in the Endoplasmic reticulum-Golgi intermediate compartment.

Topology

Cytoplasmic: 1-42
Helical: 43-63
Lumenal: 64-227

Rigby, M. J., Ding, Y., Farrugia, M. A., Feig, M., Cortese, G. P., Mitchell, H., ... & Puglielli, L. (2020). The endoplasmic reticulum acetyltransferases ATase1/NAT8B and ATase2/NAT8 are differentially regulated to adjust engagement of the secretory pathway. Journal of neurochemistry, 154(4), 404-423.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Rabbit Anti-NAT8B Recombinant Antibody (CBWJN-1180) (CAT#: CBMAB-N1228-WJ)

Isotype control

For research use only. Not intended for any clinical use.

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