NKD2

This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Full Name

Naked Cuticle Homolog 2

Function

Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity).
Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.

Biological Process

ExocytosisIEA:UniProtKB-KW
Golgi vesicle fusion to target membraneManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of protein processingManual Assertion Based On ExperimentIDA:BHF-UCL
Protein localization to plasma membraneManual Assertion Based On ExperimentIMP:BHF-UCL
Wnt signaling pathwayIEA:UniProtKB-KW

Cellular Location

Cell membrane
Cytoplasm
Cytoplasmic vesicle

PTM

Ubiquitinated, leading to rapid proteasomal degradation. Interaction with TGFA interferes with RNF25 binding and protects against ubiquitination mediated by RNF25.