NME6
The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the NM23 gene family (see MIM 156490).[supplied by OMIM
Full Name
non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)
Function
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.
Biological Process
Apoptotic processIEA:UniProtKB-KW
CTP biosynthetic processIEA:InterPro
GTP biosynthetic processIEA:InterPro
Negative regulation of cell growthManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of mitotic nuclear divisionManual Assertion Based On ExperimentIDA:UniProtKB
UTP biosynthetic processIEA:InterPro
CTP biosynthetic processIEA:InterPro
GTP biosynthetic processIEA:InterPro
Negative regulation of cell growthManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of mitotic nuclear divisionManual Assertion Based On ExperimentIDA:UniProtKB
UTP biosynthetic processIEA:InterPro
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Anti-NME6 antibodies
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Target: NME6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2A10
Application*: E, P, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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