NOCT

The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. [provided by RefSeq, Jul 2008]

Full Name

Nocturnin

Function

Phosphatase which catalyzes the conversion of NADP+ to NAD+ and of NADPH to NADH (PubMed:31147539).
Shows a small preference for NADPH over NADP+ (PubMed:31147539).
Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338).
Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity).
Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity).
Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity).
Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity).
Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity).
Critical for proper development of early embryos (By similarity).

Biological Process

Circadian regulation of gene expressionISS:UniProtKB
Deadenylation-dependent decapping of nuclear-transcribed mRNAIEA:Ensembl
mRNA stabilizationISS:UniProtKB
NADP metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of gene expressionISS:UniProtKB
Negative regulation of osteoblast differentiationISS:UniProtKB
P-body assemblyIEA:Ensembl
Positive regulation of fat cell differentiationISS:UniProtKB
Regulation of circadian rhythmISS:UniProtKB
Regulation of embryonic developmentIEA:Ensembl
Response to extracellular stimulusISS:UniProtKB
Response to lipopolysaccharideISS:UniProtKB
Transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm
Nucleus
Cytoplasm, perinuclear region
Mitochondrion