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Mouse Anti-NOCT Recombinant Antibody (CBYY-C1146) (CBMAB-C2583-YY)

This product is mouse antibody that recognizes NOCT. The antibody CBYY-C1146 can be used for immunoassay techniques such as: ELISA, WB
See all NOCT antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C1146
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein A purified
Preservative
PBS, pH 7.2
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nocturnin
Entrez Gene ID
25819
UniProt ID
Q9UK39
Alternative Names
NOC; CCR4L; Ccr4c; CCRN4L
Function
Phosphatase which catalyzes the conversion of NADP+ to NAD+ and of NADPH to NADH (PubMed:31147539).
Shows a small preference for NADPH over NADP+ (PubMed:31147539).
Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338).
Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity).
Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity).
Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity).
Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity).
Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity).
Critical for proper development of early embryos (By similarity).
Biological Process
Circadian regulation of gene expressionISS:UniProtKB
Deadenylation-dependent decapping of nuclear-transcribed mRNAIEA:Ensembl
mRNA stabilizationISS:UniProtKB
NADP metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of gene expressionISS:UniProtKB
Negative regulation of osteoblast differentiationISS:UniProtKB
P-body assemblyIEA:Ensembl
Positive regulation of fat cell differentiationISS:UniProtKB
Regulation of circadian rhythmISS:UniProtKB
Regulation of embryonic developmentIEA:Ensembl
Response to extracellular stimulusISS:UniProtKB
Response to lipopolysaccharideISS:UniProtKB
Transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Nucleus
Cytoplasm, perinuclear region
Mitochondrion

Kulshrestha, S., & Devkar, R. (2023). Circadian control of Nocturnin and its regulatory role in health and disease. Chronobiology International, 40(7), 970-981.

Wickramaratne, A. C., Li, L., Hopkins, J. B., Joachimiak, L. A., & Green, C. B. (2022). The Disordered Amino Terminus of the Circadian Enzyme Nocturnin Modulates Its NADP (H) Phosphatase Activity by Changing Protein Dynamics. Biochemistry, 61(11), 1091-1102.

Laothamatas, I. (2021). Spatiotemporal Regulation of the NADP (H) Phosphatase Nocturnin (Doctoral dissertation).

Abshire, E. T., Hughes, K., Diao, R., Pearce, S., Trievel, R. C., Rorbach, J., ... & Goldstrohm, A. C. (2020). Differential processing and localization of human Nocturnin controls metabolism of mRNA and nicotinamide dinucleotide metabolites. bioRxiv, 2020-01.

Laothamatas, I., Gao, P., Wickramaratne, A., Quintanilla, C. G., Dino, A., Khan, C. A., ... & Green, C. B. (2020). Spatiotemporal regulation of NADP (H) phosphatase Nocturnin and its role in oxidative stress response. Proceedings of the National Academy of Sciences, 117(2), 993-999.

Abshire, E. T., Hughes, K. L., Diao, R., Pearce, S., Gopalakrishna, S., Trievel, R. C., ... & Goldstrohm, A. C. (2020). Differential processing and localization of human Nocturnin controls metabolism of mRNA and nicotinamide adenine dinucleotide cofactors. Journal of Biological Chemistry, 295(44), 15112-15133.

Le, P. T., Bornstein, S. A., Motyl, K. J., Tian, L., Stubblefield, J. J., Hong, H. K., ... & Guntur, A. R. (2019). A novel mouse model overexpressing Nocturnin results in decreased fat mass in male mice. Journal of cellular physiology, 234(11), 20228-20239.

Estrella, M. A., Du, J., Chen, L., Rath, S., Prangley, E., Chitrakar, A., ... & Korennykh, A. (2019). The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled). Nature communications, 10(1), 2367.

Bracci, M., Copertaro, A., Ciarapica, V., Barbaresi, M., Esposito, S., Albanesi, A., ... & Santarelli, L. (2019). Nocturnin gene diurnal variation in healthy volunteers and expression levels in shift workers. BioMed Research International, 2019.

Onder, Y., Laothamatas, I., Berto, S., Sewart, K., Kilaru, G., Bordieanu, B., ... & Green, C. B. (2019). The circadian protein nocturnin regulates metabolic adaptation in brown adipose tissue. Iscience, 19, 83-92.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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