Mouse Anti-NOCT Recombinant Antibody (CBYY-C1146) (CBMAB-C2583-YY)

Name: Mouse Anti-NOCT Recombinant Antibody (CBYY-C1146)
SKU: CBMAB-C2583-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-C1146

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Protein A purified

Preservative

PBS, pH 7.2

Concentration

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Nocturnin

Entrez Gene ID

25819

UniProt ID

Q9UK39

Alternative Names

NOC; CCR4L; Ccr4c; CCRN4L

Function

Phosphatase which catalyzes the conversion of NADP+ to NAD+ and of NADPH to NADH (PubMed:31147539).
Shows a small preference for NADPH over NADP+ (PubMed:31147539).
Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338).
Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity).
Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity).
Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity).
Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity).
Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity).
Critical for proper development of early embryos (By similarity).

Biological Process

Circadian regulation of gene expressionISS:UniProtKB
Deadenylation-dependent decapping of nuclear-transcribed mRNAIEA:Ensembl
mRNA stabilizationISS:UniProtKB
NADP metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of gene expressionISS:UniProtKB
Negative regulation of osteoblast differentiationISS:UniProtKB
P-body assemblyIEA:Ensembl
Positive regulation of fat cell differentiationISS:UniProtKB
Regulation of circadian rhythmISS:UniProtKB
Regulation of embryonic developmentIEA:Ensembl
Response to extracellular stimulusISS:UniProtKB
Response to lipopolysaccharideISS:UniProtKB
Transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm
Nucleus
Cytoplasm, perinuclear region
Mitochondrion

Kulshrestha, S., & Devkar, R. (2023). Circadian control of Nocturnin and its regulatory role in health and disease. Chronobiology International, 40(7), 970-981.

Wickramaratne, A. C., Li, L., Hopkins, J. B., Joachimiak, L. A., & Green, C. B. (2022). The Disordered Amino Terminus of the Circadian Enzyme Nocturnin Modulates Its NADP (H) Phosphatase Activity by Changing Protein Dynamics. Biochemistry, 61(11), 1091-1102.

Laothamatas, I. (2021). Spatiotemporal Regulation of the NADP (H) Phosphatase Nocturnin (Doctoral dissertation).

Abshire, E. T., Hughes, K., Diao, R., Pearce, S., Trievel, R. C., Rorbach, J., ... & Goldstrohm, A. C. (2020). Differential processing and localization of human Nocturnin controls metabolism of mRNA and nicotinamide dinucleotide metabolites. bioRxiv, 2020-01.

Laothamatas, I., Gao, P., Wickramaratne, A., Quintanilla, C. G., Dino, A., Khan, C. A., ... & Green, C. B. (2020). Spatiotemporal regulation of NADP (H) phosphatase Nocturnin and its role in oxidative stress response. Proceedings of the National Academy of Sciences, 117(2), 993-999.

Abshire, E. T., Hughes, K. L., Diao, R., Pearce, S., Gopalakrishna, S., Trievel, R. C., ... & Goldstrohm, A. C. (2020). Differential processing and localization of human Nocturnin controls metabolism of mRNA and nicotinamide adenine dinucleotide cofactors. Journal of Biological Chemistry, 295(44), 15112-15133.

Le, P. T., Bornstein, S. A., Motyl, K. J., Tian, L., Stubblefield, J. J., Hong, H. K., ... & Guntur, A. R. (2019). A novel mouse model overexpressing Nocturnin results in decreased fat mass in male mice. Journal of cellular physiology, 234(11), 20228-20239.

Estrella, M. A., Du, J., Chen, L., Rath, S., Prangley, E., Chitrakar, A., ... & Korennykh, A. (2019). The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled). Nature communications, 10(1), 2367.

Bracci, M., Copertaro, A., Ciarapica, V., Barbaresi, M., Esposito, S., Albanesi, A., ... & Santarelli, L. (2019). Nocturnin gene diurnal variation in healthy volunteers and expression levels in shift workers. BioMed Research International, 2019.

Onder, Y., Laothamatas, I., Berto, S., Sewart, K., Kilaru, G., Bordieanu, B., ... & Green, C. B. (2019). The circadian protein nocturnin regulates metabolic adaptation in brown adipose tissue. Iscience, 19, 83-92.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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