NR2E1

NR2E1 is an orphan receptor involved in retinal development. NR2E1 also regulates adult neural stem cell proliferation and may be involved in control of aggressive behavior.

Full Name

nuclear receptor subfamily 2, group E, member 1

Function

Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity).
May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity).
May be involved in retinoic acid receptor (RAR) regulation in retinal cells.

Biological Process

Aggressive behaviorIEA:Ensembl
Amygdala developmentIEA:Ensembl
Anatomical structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Anterior commissure morphogenesisIEA:Ensembl
Behavioral fear responseIEA:Ensembl
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Cell fate commitmentIEA:Ensembl
Cerebral cortex neuron differentiationIEA:Ensembl
Dentate gyrus developmentIEA:Ensembl
Extracellular matrix organizationIEA:Ensembl
Forebrain generation of neuronsIEA:Ensembl
Layer formation in cerebral cortexIEA:Ensembl
Long-term synaptic potentiationIEA:Ensembl
Negative regulation of apoptotic processIEA:Ensembl
Negative regulation of astrocyte differentiationIEA:Ensembl
Negative regulation of neural precursor cell proliferationIEA:Ensembl
Negative regulation of neuron differentiationIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Olfactory bulb developmentIEA:Ensembl
Positive regulation of angiogenesisIEA:Ensembl
Positive regulation of cell cycleIEA:Ensembl
Positive regulation of neural precursor cell proliferationIEA:Ensembl
Positive regulation of stem cell proliferationIEA:Ensembl
Regulation of cell migration involved in sprouting angiogenesisIEA:Ensembl
Regulation of dendrite morphogenesisIEA:Ensembl
Regulation of timing of neuron differentiationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Retina development in camera-type eyeIEA:Ensembl
Social behaviorIEA:Ensembl
Somatic stem cell population maintenanceIEA:Ensembl
Visual perceptionIEA:Ensembl

Cellular Location

Nucleus