OSBPL8

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Full Name

oxysterol binding protein-like 8

Function

Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935).
Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267).

Biological Process

Activation of protein kinase B activityISS:BHF-UCL
Fat cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of cell migrationIEA:Ensembl
Negative regulation of sequestering of triglycerideManual Assertion Based On ExperimentIDA:BHF-UCL
Phosphatidylserine acyl-chain remodelingTAS:Reactome
Phospholipid transportManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of glucose importISS:BHF-UCL
Positive regulation of insulin receptor signaling pathwayIEA:Ensembl
Positive regulation of protein kinase B signalingISS:BHF-UCL
Protein localization to nuclear poreIEA:Ensembl

Cellular Location

Isoform 1
Endoplasmic reticulum membrane
Nucleus membrane
The presence of the N-terminus extension contains an overall negative charge that may explain the weak localization to the cortical endoplasmic reticulum (Probable).
Isoform 3
Endoplasmic reticulum membrane
Localizes to the cortical endoplasmic reticulum at the endoplasmic reticulum-plasma membrane contact sites.

Topology

Helical: 871-888