Mouse Anti-OSBPL8 (AA 244-347) Recombinant Antibody (CBXO-0459) (CBMAB-O0597-CQ)

Name: Mouse Anti-OSBPL8 (AA 244-347) Recombinant Antibody (CBXO-0459)
SKU: CBMAB-O0597-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXO-0459

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa244-347 from human OSBPL8 (NP_065892) with GST tag

Specificity

Human

Antibody Isotype

IgG2a, Κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 244-347

More Infomation

Target

Full Name

oxysterol binding protein-like 8

Introduction

This gene encodes a member of a family of proteins containing an N-terminal pleckstrin homology domain and a highly conserved C-terminal oxysterol-binding protein-like sterol-binding domain. It binds mutliple lipid-containing molecules, including phosphatidylserine, phosphatidylinositol 4-phosphate (PI4P) and oxysterol, and promotes their exchange between the endoplasmic reticulum and the plasma membrane. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

114882

UniProt ID

Q9BZF1

Alternative Names

Oxysterol Binding Protein Like 8; OSBP-Related Protein 8; OSBP10; ORP8; Oxysterol-Binding Protein-Related Protein 8; Oxysterol Binding Protein-Like 8

Function

Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935).
Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267).

Biological Process

Activation of protein kinase B activityISS:BHF-UCL
Fat cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of cell migrationIEA:Ensembl
Negative regulation of sequestering of triglycerideManual Assertion Based On ExperimentIDA:BHF-UCL
Phosphatidylserine acyl-chain remodelingTAS:Reactome
Phospholipid transportManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of glucose importISS:BHF-UCL
Positive regulation of insulin receptor signaling pathwayIEA:Ensembl
Positive regulation of protein kinase B signalingISS:BHF-UCL
Protein localization to nuclear poreIEA:Ensembl

Cellular Location

Isoform 1
Endoplasmic reticulum membrane
Nucleus membrane
The presence of the N-terminus extension contains an overall negative charge that may explain the weak localization to the cortical endoplasmic reticulum (Probable).
Isoform 3
Endoplasmic reticulum membrane
Localizes to the cortical endoplasmic reticulum at the endoplasmic reticulum-plasma membrane contact sites.

Topology

Helical: 871-888

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-OSBPL8 Recombinant Antibody (CBXO-0489) (CAT#: CBMAB-O0596-CQ)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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