P2RY1

P2RY1 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.

Purinergic Receptor P2Y1

Receptor for extracellular adenine nucleotides such as ADP (PubMed:9442040, PubMed:9038354, PubMed:25822790).
In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040).

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
AgingIEA:Ensembl
Blood vessel diameter maintenanceIEA:Ensembl
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to ATPManual Assertion Based On ExperimentTAS:ARUK-UCL
Cellular response to purine-containing compoundManual Assertion Based On ExperimentIMP:UniProtKB
Eating behaviorIEA:Ensembl
G protein-coupled adenosine receptor signaling pathwayIEA:Ensembl
G protein-coupled receptor signaling pathwayISS:BHF-UCL
Glial cell migrationIEA:Ensembl
Negative regulation of bindingIEA:Ensembl
Negative regulation of norepinephrine secretionIEA:Ensembl
Phospholipase C-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Platelet activationIEA:InterPro
Positive regulation of cytosolic calcium ion concentrationISS:BHF-UCL
Positive regulation of ERK1 and ERK2 cascadeISS:BHF-UCL
Positive regulation of hormone secretionIEA:Ensembl
Positive regulation of inositol trisphosphate biosynthetic processIEA:Ensembl
Positive regulation of ion transportIEA:Ensembl
Positive regulation of penile erectionIEA:Ensembl
Positive regulation of protein phosphorylationISS:BHF-UCL
Positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Protein localization to plasma membraneISS:BHF-UCL
Regulation of cell shapeManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of presynaptic cytosolic calcium ion concentrationIEA:Ensembl
Regulation of signaling receptor activityIEA:Ensembl
Regulation of synaptic vesicle exocytosisIEA:Ensembl
Relaxation of muscleIEA:InterPro
Response to growth factorIEA:Ensembl
Response to mechanical stimulusIEA:Ensembl
Sensory perception of painIEA:Ensembl
Signal transduction involved in regulation of gene expressionISS:BHF-UCL

Cell membrane

Extracellular: 1-51
Helical: 52-74
Cytoplasmic: 75-87
Helical: 88-109
Extracellular: 110-125
Helical: 126-147
Cytoplasmic: 148-166
Helical: 167-188
Extracellular: 189-214
Helical: 215-237
Cytoplasmic: 238-260
Helical: 261-284
Extracellular: 285-303
Helical: 304-325
Cytoplasmic: 326-373