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PDIA2

PDIA2 is a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. The protein plays a role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds through its thiol isomerase, oxidase, and reductase activity. The encoded protein also possesses estradiol-binding activity and can modulate intracellular estradiol levels.
Full Name
Protein Disulfide Isomerase Family A Member 2
Function
Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins.
Biological Process
Protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Protein folding in endoplasmic reticulumManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Protein retention in ER lumenManual Assertion Based On ExperimentTAS:ProtInc
Response to endoplasmic reticulum stressManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Endoplasmic reticulum lumen
PTM
The disulfide-linked homodimer exhibits an enhanced chaperone activity.
Glycosylated.

Anti-PDIA2 antibodies

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Target: PDIA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Mouse, Rat
Clone: 34/PDI
Application*: WB, IF
Target: PDIA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Sheep, Rabbit, Chicken, Guinea pig, Hamster, Cattle, Dog, Pig, Frog, Monkey
Clone: 1D3
Application*: F
Target: PDIA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Hamster, Pig, Frog
Clone: RL77
Application*: WB, IP, E, P, IC, GSA, F, IF
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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