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Mouse Anti-PDIA2 Recombinant Antibody (RL77) (CBMAB-P1292-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Disulfide Isomerase Family A Member 2. The antibody can be used for immunoassay techniques, such as WB, IP, ELISA, IHC-P, ICC, GSA, FC, IF.
See all PDIA2 antibodies
Published Data
Fig.1 HEK293TN cells were transfected with the indicated plasmids, and Western blot analyses with the indicated antibodies of input lysates and pulldown eluates after affinity chromatography were performed.
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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Hamster, Pig, Frog
Clone
RL77
Antibody Isotype
IgG2b
Application
WB, IP, ELISA, IHC-P, ICC, GSA, FC, IF

Basic Information

Specificity
Human, Mouse, Rat, Hamster, Pig, Frog
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein Disulfide Isomerase Family A Member 2
Introduction
PDIA2 is a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. The protein plays a role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds through its thiol isomerase, oxidase, and reductase activity. The encoded protein also possesses estradiol-binding activity and can modulate intracellular estradiol levels.
Entrez Gene ID
Human64714
Mouse69191
Rat287164
Hamster101837626
Pig100738360
Frog496734
UniProt ID
HumanQ13087
MouseD3Z6P0
HamsterA0A1U7QV55
PigA0A287A8T4
FrogQ6V4H6
Alternative Names
Protein Disulfide Isomerase Family A Member 2; Pancreas-Specific Protein Disulfide Isomerase; Protein Disulfide Isomerase-Associated 2; Protein Disulfide Isomerase, Pancreatic; EC 5.3.4.1; PDIP; Protein Disulfide Isomerase Family A, Member 2;
Function
Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins.
Biological Process
Protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Protein folding in endoplasmic reticulumManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Protein retention in ER lumenManual Assertion Based On ExperimentTAS:ProtInc
Response to endoplasmic reticulum stressManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Endoplasmic reticulum lumen
PTM
The disulfide-linked homodimer exhibits an enhanced chaperone activity.
Glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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