PDLIM1

This gene encodes a member of the enigma protein family. The protein contains two protein interacting domains, a PDZ domain at the amino terminal end and one to three LIM domains at the carboxyl terminal. It is a cytoplasmic protein associated with the cytoskeleton. The protein may function as an adapter to bring other LIM-interacting proteins to the cytoskeleton. Pseudogenes associated with this gene are located on chromosomes 3, 14 and 17. [provided by RefSeq, Oct 2012]

PDZ And LIM Domain 1

Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853).
Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity).

Actin cytoskeleton organizationISS:UniProtKB
Establishment or maintenance of actin cytoskeleton polarityISS:UniProtKB
Fibroblast migrationISS:UniProtKB
Heart developmentManual Assertion Based On ExperimentIBA:GO_Central
Maintenance of cell polarityISS:UniProtKB
Muscle structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Response to oxidative stressManual Assertion Based On ExperimentTAS:ProtInc
Stress fiber assemblyISS:UniProtKB

Cytoplasm
Cytoplasm, cytoskeleton
Cytoplasm, myofibril, sarcomere, Z line
Associates with actin stress fibers.