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Mouse Anti-PDLIM1 Recombinant Antibody (CBYC-P273) (CBMAB-P1329-YC)

Provided herein is a Mouse monoclonal antibody against Human PDZ And LIM Domain 1. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PDLIM1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P273
Antibody Isotype
IgG2a
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2, 0.09% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 123-233

Target

Full Name
PDZ And LIM Domain 1
Introduction
PDLIM1 is a member of the enigma protein family. The protein contains two protein interacting domains, a PDZ domain at the amino terminal end and one to three LIM domains at the carboxyl terminal. It is a cytoplasmic protein associated with the cytoskeleton. The protein may function as an adapter to bring other LIM-interacting proteins to the cytoskeleton. Pseudogenes associated with this gene are located on chromosomes 3, 14 and 17.
Entrez Gene ID
9124
UniProt ID
O00151
Alternative Names
PDZ And LIM Domain 1; Elfin; Carboxyl Terminal LIM Domain Protein 1; LIM Domain Protein CLP-36; CLIM1; CLP36; Epididymis Secretory Protein Li 112;
Function
Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853).
Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity).
Biological Process
Actin cytoskeleton organizationISS:UniProtKB
Establishment or maintenance of actin cytoskeleton polarityISS:UniProtKB
Fibroblast migrationISS:UniProtKB
Heart developmentManual Assertion Based On ExperimentIBA:GO_Central
Maintenance of cell polarityISS:UniProtKB
Muscle structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Response to oxidative stressManual Assertion Based On ExperimentTAS:ProtInc
Stress fiber assemblyISS:UniProtKB
Cellular Location
Cytoplasm
Cytoplasm, cytoskeleton
Cytoplasm, myofibril, sarcomere, Z line
Associates with actin stress fibers.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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