PEX11B

PEX11B facilitates peroxisomal proliferation and interacts with PEX19. The encoded protein is found in the peroxisomal membrane.

Full Name

peroxisomal biogenesis factor 11 beta

Function

Involved in peroxisomal proliferation (PubMed:9792670).
May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane (PubMed:12618434).
Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455).

Biological Process

Peroxisome fissionManual Assertion Based On ExperimentIDA:UniProtKB
Peroxisome organizationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of peroxisome sizeManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionISS:UniProtKB

Cellular Location

Peroxisome membrane

Involvement in disease

Peroxisome biogenesis disorder 14B (PBD14B):
An autosomal recessive peroxisome biogenesis disorder characterized clinically by mild intellectual disability, congenital cataracts, progressive hearing loss, and polyneuropathy. Additionally, recurrent migraine-like episodes following mental stress or physical exertion, not a common feature in peroxisome disorders, are observed.

Topology

Helical: 233-255