PEX11B

PEX11B facilitates peroxisomal proliferation and interacts with PEX19. The encoded protein is found in the peroxisomal membrane.

Full Name

peroxisomal biogenesis factor 11 beta

Function

Involved in peroxisomal proliferation (PubMed:9792670).
May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane (PubMed:12618434).
Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455).

Biological Process

Peroxisome fissionManual Assertion Based On ExperimentIDA:UniProtKB
Peroxisome organizationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of peroxisome sizeManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionISS:UniProtKB

Cellular Location

Peroxisome membrane

Involvement in disease

Peroxisome biogenesis disorder 14B (PBD14B):
An autosomal recessive peroxisome biogenesis disorder characterized clinically by mild intellectual disability, congenital cataracts, progressive hearing loss, and polyneuropathy. Additionally, recurrent migraine-like episodes following mental stress or physical exertion, not a common feature in peroxisome disorders, are observed.

Topology

Helical: 233-255

Anti-PEX11B antibodies

Mouse Anti-PEX11B Recombinant Antibody (CBYC-P300) (CBMAB-P1470-YC)

Datasheet

SDS

Target: PEX11B

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYC-P300

Application*: E, P

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)