Mouse Anti-PEX11B Recombinant Antibody (CBYC-P300) (CBMAB-P1470-YC)

Name: Mouse Anti-PEX11B Recombinant Antibody (CBYC-P300)
SKU: CBMAB-P1470-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBYC-P300

Application

ELISA, IHC-P

Immunogen

PEX11B (NP_003837.1, 1-98 aa) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

peroxisomal biogenesis factor 11 beta

Introduction

PEX11B facilitates peroxisomal proliferation and interacts with PEX19. The encoded protein is found in the peroxisomal membrane.

Entrez Gene ID

8799

UniProt ID

O96011

Alternative Names

PEX14B; PEX11-BETA

Function

Involved in peroxisomal proliferation (PubMed:9792670).
May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane (PubMed:12618434).
Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455).

Biological Process

Peroxisome fissionManual Assertion Based On ExperimentIDA:UniProtKB
Peroxisome organizationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of peroxisome sizeManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionISS:UniProtKB

Cellular Location

Peroxisome membrane

Involvement in disease

Peroxisome biogenesis disorder 14B (PBD14B):
An autosomal recessive peroxisome biogenesis disorder characterized clinically by mild intellectual disability, congenital cataracts, progressive hearing loss, and polyneuropathy. Additionally, recurrent migraine-like episodes following mental stress or physical exertion, not a common feature in peroxisome disorders, are observed.

Topology

Helical: 233-255

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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