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Mouse Anti-PEX11B Recombinant Antibody (CBYC-P300) (CBMAB-P1470-YC)

Provided herein is a Mouse monoclonal antibody against Human Peroxisomal biogenesis factor 11 beta. The antibody can be used for immunoassay techniques, such as ELISA, IHC-P.
See all PEX11B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P300
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC-P

Basic Information

Immunogen
PEX11B (NP_003837.1, 1-98 aa) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
peroxisomal biogenesis factor 11 beta
Introduction
PEX11B facilitates peroxisomal proliferation and interacts with PEX19. The encoded protein is found in the peroxisomal membrane.
Entrez Gene ID
8799
UniProt ID
O96011
Alternative Names
PEX14B; PEX11-BETA
Function
Involved in peroxisomal proliferation (PubMed:9792670).
May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane (PubMed:12618434).
Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455).
Biological Process
Peroxisome fissionManual Assertion Based On ExperimentIDA:UniProtKB
Peroxisome organizationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of peroxisome sizeManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionISS:UniProtKB
Cellular Location
Peroxisome membrane
Involvement in disease
Peroxisome biogenesis disorder 14B (PBD14B):
An autosomal recessive peroxisome biogenesis disorder characterized clinically by mild intellectual disability, congenital cataracts, progressive hearing loss, and polyneuropathy. Additionally, recurrent migraine-like episodes following mental stress or physical exertion, not a common feature in peroxisome disorders, are observed.
Topology
Helical: 233-255
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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