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PGGT1B

Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine. The enzyme is composed of a 48-kD alpha subunit and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.

Full Name

Protein Geranylgeranyltransferase Type I Subunit Beta

Function

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B.

Biological Process

Protein geranylgeranylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein prenylationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

CAAX-protein geranylgeranyltransferase complex

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Anti-PGGT1B antibodies

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Mouse Anti-PGGT1B Recombinant Antibody (CBYC-P325) (CBMAB-P1577-YC)

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Target: PGGT1B

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYC-P325

Application*: E, IC, WB

Mouse Anti-PGGT1B Recombinant Antibody (5E4) (CBMAB-P1576-YC)

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Target: PGGT1B

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 5E4

Application*: E, IF, P, WB

Mouse Anti-PGGT1B Recombinant Antibody (CBLG1-3238) (CBMAB-G6446-LY)

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Target: PGGT1B

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-3238

Application*: WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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