PGGT1B

Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine. The enzyme is composed of a 48-kD alpha subunit and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.

Protein Geranylgeranyltransferase Type I Subunit Beta

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B.

Protein geranylgeranylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein prenylationManual Assertion Based On ExperimentIBA:GO_Central

CAAX-protein geranylgeranyltransferase complex