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Mouse Anti-PGGT1B Recombinant Antibody (5E4) (CBMAB-P1576-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Geranylgeranyltransferase Type I Subunit Beta. The antibody can be used for immunoassay techniques, such as ELISA, IF, IHC-P, WB.
See all PGGT1B antibodies
Published Data
Fig.1 Inactivating GGTase-I in skin keratinocytes.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
5E4
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein Geranylgeranyltransferase Type I Subunit Beta
Introduction
Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine. The enzyme is composed of a 48-kD alpha subunit and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.
Entrez Gene ID
5229
UniProt ID
P53609
Alternative Names
Protein Geranylgeranyltransferase Type I Subunit Beta; Protein Geranylgeranyltransferase Type I, Beta Subunit; Type I Protein Geranyl-Geranyltransferase Subunit Beta; Geranylgeranyl Transferase Type I Subunit Beta; GGTase-I-Beta; EC 2.5.1.59; Geranylgeranyl Transferase Type-1 Subunit Beta;
Function
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B.
Biological Process
Protein geranylgeranylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein prenylationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
CAAX-protein geranylgeranyltransferase complex
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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